Journal
NEURORADIOLOGY
Volume 63, Issue 12, Pages 2153-2156Publisher
SPRINGER
DOI: 10.1007/s00234-021-02829-1
Keywords
COVID-19; Leukoencephalopathy; Chronic; Neuroimaging; MRI
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Long-term neurological manifestations of COVID-19 are increasingly being reported, with COVID-19-related leukoencephalopathy potentially leading to chronic deficits, irreversible white matter damage, and poor prognostication of neurologic recovery.
More than a year after the start of the COVID-19 pandemic, long-term neurological manifestations of COVID-19 are increasingly being reported. The long-term sequelae of COVID-19-related leukoencephalopathy, however, remain unclear. Here, we present long-term neuroimaging follow-up in two cases of COVID-19-related leukoencephalopathy. The two cases demonstrate the utility of brain MRI for evaluating neurologic symptoms in critically ill patients with COVID-19, for diagnosis of underlying neural injury and prognostication of future recovery. The presence of leukoencephalopathy may result in chronic neurologic manifestations and may represent a poor prognosticator of neurologic recovery. The presence of leukoencephalomalacia on follow-up neuroimaging is potentially an indicator of irreversible white matter damage, which may be associated with more severe chronic deficits.
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