Superfood for axons: Glial exosomes boost axonal energetics by delivery of SIRT2

Axon integrity depends on support by glia facilitating axonal maintenance , energy homeostasis, but the molecular mechanisms are not well understood. In this issue of Neuron, Chamberlain et al. specialIntscript provide evidence that oligodendrocyte-to-axon transfer of SIRT2 via extracellular vesicles (exosomes) enables deacetylation of mitochondrial proteins, enhancing axonal energy production.

Automated summary

Axon integrity relies on support from glial cells for maintenance and energy balance. The transfer of SIRT2 from oligodendrocytes to axons via extracellular vesicles enhances axonal energy production by deacetylating mitochondrial proteins.