Brain ventricles as windows into brain development and disease

Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.

Automated summary

Dilation of fluid-filled cerebral ventricles, known as ventriculomegaly, is a common feature of hydrocephalus and is often seen in autism and schizophrenia. Recent research indicates that studying the genomics of congenital hydrocephalus may provide valuable insights into neural stem cell regulation, human cerebrocortical development, and the pathogenesis of neuropsychiatric diseases.