Journal
NEURON
Volume 109, Issue 22, Pages 3576-3593Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2021.08.036
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Funding
- Center for New Scientists at the Weizmann Institute of Science
- Israeli Council for Higher Education
- NIH [DP1 AT010971, R01 DK109930]
- McKnight Foundation
- Klarman Family Foundation
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Our wellness is dependent on continuous interactions between the brain and body, with the insular cortex playing a key role in predictive processing. Recent studies on cellular activity in the rodent insular cortex provide a unifying heuristic model for guiding future research.
Our wellness relies on continuous interactions between our brain and body: different organs relay their current state to the brain and are regulated, in turn, by descending visceromotor commands from our brain and by actions such as eating, drinking, thermotaxis, and predator escape. Human neuroimaging and theoretical studies suggest a key role for predictive processing by insular cortex in guiding these efforts to maintain bodily homeostasis. Here, we review recent studies recording and manipulating cellular activity in rodent insular cortex at timescales from seconds to hours. We argue that consideration of these findings in the context of predictive processing of future bodily states may reconcile several apparent discrepancies and offer a unifying, heuristic model for guiding future work.
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