4.3 Article

Gradation of Clinical Holistic Response as New Composite Outcome to Evaluate Success in Spinal Cord Stimulation Studies for Pain

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Improved Psychosocial and Functional Outcomes and Reduced Opioid Usage Following Burst Spinal Cord Stimulation

Steven M. Falowski et al.

Summary: The study showed that Burst spinal cord stimulation (B-SCS) can reduce neuronal firing in the anterior cingulate cortex through selective modulation of the medial pain pathway tract, improving psychosocial functioning and quality of life in patients with chronic, intractable pain. Significant improvements were observed in pain, physical, mental, and emotional functioning at 6- and 12-month follow-ups, with 81% of subjects satisfied with their therapy. Additionally, improvements in mental health outcomes were associated with enhanced pain relief and quality of life scores, leading to a reduced need for opioids and overall better outcomes.

NEUROMODULATION (2021)

Article Medicine, Research & Experimental

Composite Score Is a Better Reflection of Patient Response to Chronic Pain Therapy Compared With Pain Intensity Alone

Julie G. Pilitsis et al.

Summary: This study proposes a multidimensional responder index and emphasizes the importance of using composite endpoints for a more meaningful response measure in chronic pain therapies. The analysis showed that pain score should not be used alone, and subjects who failed to respond on NRS showed response on other measures, indicating the multidimensional nature of therapeutic response similar to the chronic pain experience.

NEUROMODULATION (2021)

Article Medicine, Research & Experimental

How Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double-Blind, Controlled Trial (ESTIMETStudy)

Philippe Rigoard et al.

Summary: The study compared clinical outcomes of refractory postoperative chronic back pain patients implanted with multicolumn SCS using either multicolumn or monocolumn programming. Results showed significant improvements in pain scores for patients receiving multicolumn SCS for at least six months, regardless of the programming method. The study confirms the benefits of multicolumn SCS for chronic back pain, suggesting that the specific architecture of the multicolumn lead allows for optimized neural targeting with low-energy requirements.

NEUROMODULATION (2021)

Article Anesthesiology

High-dose spinal cord stimulation for patients with failed back surgery syndrome: a multicenter effectiveness and prediction study

Lisa Goudman et al.

Summary: High-dose spinal cord stimulation (HD-SCS) has shown significant and sustained pain relief over a period of 12 months in patients with failed back surgery syndrome (FBSS). Additionally, HD-SCS resulted in improvement in sleep quality, functionality, and a decrease in pain medication usage.
Review Anesthesiology

10 kHz Spinal Cord Stimulation for the Treatment of Failed Back Surgery Syndrome with Predominant Leg Pain: Results from a Prospective Study in Patients from the Dutch Healthcare System

Jan Willem Kallewaard et al.

Summary: This study evaluated the safety and efficacy of 10 kHz SCS in FBSS patients with predominant leg pain, showing that the therapy is both safe and effective, leading to improved quality of life for patients.

PAIN PRACTICE (2021)

Review Anesthesiology

Persistent Spinal Pain Syndrome: A Proposal for Failed Back Surgery Syndrome and ICD-11

Nick Christelis et al.

Summary: The term "Failed back surgery syndrome (FBSS)" is considered inadequate and misleading for describing patients with persistent pain following spine surgery. The International Association for the Study of Pain (IASP) proposed "Chronic pain after spinal surgery (CPSS)" as a replacement term, which is now accepted by the World Health Organization (WHO). Through a structured workshop and Delphi process, "Persistent spinal pain syndrome" was selected as a preferred option and suggested for adoption to strengthen the new ICD-11 classification.

PAIN MEDICINE (2021)

Article Anesthesiology

Identifying goals in patients with chronic pain: A European survey

Lisa Goudman et al.

Summary: Chronic pain patients primarily aim to participate in family and social activities, reduce pain, and handle household tasks. Pain reduction remains the highest ranked goal, followed by improving sleep and participating in social activities, with walking being a crucial component for achieving all goals.

EUROPEAN JOURNAL OF PAIN (2021)

Article Medicine, Research & Experimental

Cross-Country Differences in Pain Medication Before and After Spinal Cord Stimulation: A Pooled Analysis of Individual Patient Data From Two Prospective Studies in the United Kingdom and Belgium

Lisa Goudman et al.

Summary: The study analyzed differences in prescription practices of SCS implantation patients between Belgium and the United Kingdom, revealing that NSAIDs and neuropathic mood agents are more frequently used in the UK. After three months of SCS, a decrease in medication use is observed in both countries, with higher reductions in Belgium, presumably due to strict regulations concerning reimbursement criteria.

NEUROMODULATION (2021)

Article Medicine, Research & Experimental

A Novel Composite Metric for Predicting Patient Satisfaction With Spinal Cord Stimulation

Marc Russo et al.

NEUROMODULATION (2020)

Review Clinical Neurology

The minimum clinically important difference: which direction to take

T. H. P. Draak et al.

EUROPEAN JOURNAL OF NEUROLOGY (2019)

Article Otorhinolaryngology

Understanding the Minimal Clinically Important Difference (MCID) of Patient-Reported Outcome Measures

Ahmad R. Sedaghat

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2019)

Article Health Care Sciences & Services

Chronic back pain and its association with quality of life in a large French population survey

Mathilde M. Husky et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2018)

Review Psychiatry

Pain and Depression: A Systematic Review

Waguih William IsHak et al.

HARVARD REVIEW OF PSYCHIATRY (2018)

Article Nursing

Composite Variables When and How

Mi-Kyung Song et al.

NURSING RESEARCH (2013)

Article Clinical Neurology

Back Pain: A Real Target for Spinal Cord Stimulation?

Philippe Rigoard et al.

NEUROSURGERY (2012)

Article Rehabilitation

Clinimetrics corner: a closer look at the minimal clinically important difference (MCID)

Alexis Wright et al.

JOURNAL OF MANUAL & MANIPULATIVE THERAPY (2012)

Article Pharmacology & Pharmacy

Missing Data Handling in Chronic Pain Trials

Yongman Kim

JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2011)

Article Medicine, General & Internal

Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review

Gloria Cordoba et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

Article Orthopedics

Prevalence of widespread pain and associations with work status:: a population study

Bjoern Gerdle et al.

BMC MUSCULOSKELETAL DISORDERS (2008)

Article Respiratory System

Validation of a guideline-based composite outcome assessment tool for asthma control

Sally Spencer et al.

RESPIRATORY RESEARCH (2007)

Review Clinical Neurology

Pain assessment

M Haefeli et al.

EUROPEAN SPINE JOURNAL (2006)

Article Medicine, General & Internal

Validity of composite end points in clinical trials

VM Montori et al.

BMJ-BRITISH MEDICAL JOURNAL (2005)

Article Medicine, General & Internal

EQ-5D: a measure of health status from the EuroQol Group

R Rabin et al.

ANNALS OF MEDICINE (2001)