Journal
INFLAMMATORY BOWEL DISEASES
Volume 22, Issue 3, Pages 709-718Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/MIB.0000000000000717
Keywords
metagenomics; microbiome; ulcerative colitis; bioinformatics; Crohn's disease
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Funding
- NASPGHAN/CCFA Young Investigator Development award
- Nova Scotia Health Research Foundation (NSHRF)
- Future Leaders in Inflammatory Bowel Disease (FLIBD) Program grant
- Dalhousie Medical Research Foundation
- Canadian Institutes of Health Research (CIHR)-CAG-CCC New Investigator Award [201412XGP-340307-205026]
- NSHRF Development and Innovation Grant
- Canadian Institutes of Health Research [CMF-108026]
- Atlantic Computational Excellence Network [ACEnet 2011-2285]
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Detailed analyses of the gut microbiome and its effect on human physiology and disease are emerging, thanks to advances in high-throughput DNA-sequencing technology and the burgeoning field of metagenomics. Metagenomics examines the structure and functional potential of microbial communities in their native habitats through the direct isolation and analysis of community DNA. In inflammatory bowel disease, gut microbiome studies have shown an association with perturbations in community composition and, especially, function. In this review, we discuss the application of next-generation sequencing to microbiome research and highlight the importance of modeling microbiome structure and function to the future of inflammatory bowel disease research and treatment.
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