SARS-CoV-2 vaccine-related neurological complications

Article Clinical Neurology

Cytokine release syndrome-associated encephalopathy in patients with COVID-19

P. Perrin et al.

Summary: This study found that patients with COVID-19 can develop a range of neurological manifestations, including various symptoms and laboratory abnormalities, with brain magnetic resonance imaging showing different brain abnormalities. Treatment with corticosteroids and intravenous immunoglobulins may help in the rapid recovery from neurological disturbances.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Editorial Material Clinical Neurology

ANA Investigates: Neurological Complications of COVID-19 Vaccines

Adeline L. Goss et al.

ANNALS OF NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection

Martina Patone et al.

Summary: Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to concerns in regulatory, clinical, and public health sectors. A self-controlled case series study in England showed an increased risk of rare neurological complications following COVID-19 vaccination and infection. The study highlighted a higher risk of Guillain-Barre syndrome after ChAdOx1nCoV-19 vaccination.

NATURE MEDICINE (2021)

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Article Clinical Neurology

COVID-19-related neuropathology and microglial activation in elderly with and without dementia

Tino Emanuele Poloni et al.

Summary: The study compared 9 COVID-19 cases and 6 non-COVID controls, finding non-specific changes in COVID-19 patients such as hypoxic-agonal alterations and various degrees of neurodegeneration. COVID-19 brains exhibited increased microglial activation, with a possible boosting of innate immunity and suppression of adaptive immunity. The microglial hyperactivation in the brainstem and hippocampus of COVID-19 patients with delirium appears to be a specific topographical phenomenon, potentially representing the neuropathological basis of COVID-19 encephalopathic syndrome in the elderly.

BRAIN PATHOLOGY (2021)

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Article Clinical Neurology