Journal
NEUROIMAGE
Volume 243, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2021.118471
Keywords
Dynamic functional connectivity; Callosal agenesis; Subcortical networks; Brain plasticity
Funding
- Boninchi Foundation from the University of Geneva
- Victorian Government's Operational Infrastructure Support Program
- Murdoch Children's Research Institute
- Swiss National Science Foundation [205321_163376]
- European Research Council [682734]
- Melbourne Children's Clinician Scientist Fellowship
- Australian National Health and Medical Research Council
- Swiss National Science Foundation (SNF) [205321_163376] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [682734] Funding Source: European Research Council (ERC)
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The corpus callosum is the major white-matter commissural tract connecting the two cerebral hemispheres in the human brain. Despite developmental absence of the corpus callosum, functional connectivity is preserved, with increased activation of cerebellum and amygdala/hippocampus networks observed in individuals with agenesis of the corpus callosum.
In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.
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