Tractography methods and findings in brain tumors and traumatic brain injury

White matter fiber tracking using diffusion magnetic resonance imaging (dMRI) provides a noninvasive approach to map brain connections, but improving anatomical accuracy has been a significant challenge since the birth of tractography methods. Utilizing tractography in brain studies therefore requires understanding of its technical limitations to avoid shortcomings and pitfalls. This review explores tractography limitations and how different white matter pathways pose different challenges to fiber tracking methodologies. We summarize the pros and cons of commonly-used methods, aiming to inform how tractography and its related analysis may lead to questionable results. Extending these experiences, we review the clinical utilization of tractography in patients with brain tumors and traumatic brain injury, starting from tensor-based tractography to more advanced methods. We discuss current limitations and highlight novel approaches in the context of these two conditions to inform future tractography developments.

Automated summary

This review discusses the challenges of anatomical accuracy in fiber tracking, explores the impact of different white matter pathways on tracking methods, and summarizes the pros and cons of commonly-used techniques. Additionally, it introduces the progress in clinical applications of tractography in patients with brain tumors and traumatic brain injury, highlighting current limitations and future directions for development.