Journal
INFLAMMATION
Volume 40, Issue 1, Pages 195-204Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-016-0469-1
Keywords
cytokine; experimental autoimmune encephalomyelitis; multiple sclerosis; transcription factor
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Funding
- Ministry of Science and Technology of China [2014CB541903, 2012CB910404]
- National Natural Science Foundation of China [31171348, 31371414]
- Shanghai Municipal Education Commission [14zz042]
- State Key Laboratory of Drug Research [SIMM1302KF-09]
- Fundamental Research Funds for the Central Universities
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Multiple sclerosis is a CD4(+) T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4(+) T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy.
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