Journal
INFLAMMATION
Volume 39, Issue 4, Pages 1319-1333Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-016-0364-9
Keywords
resolvin; lung ischemia/reperfusion injury; complement; immunoglobulin; inflammation; oxidative stress
Categories
Funding
- Opening Foundation of Key clinical specialized subject for the Chinese Ministry of Health-pediatric respiratory medicine [2013005]
- Key Discipline Program of Pediatric Surgery of Health Bereau of Zhejiang Province [11-ZC27]
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Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and the potential mechanisms involved. The results revealed that the levels of complement, immunoglobulin, cytokines, sICAM-1, MPO, MDA, CINC-1, MCP-1, ANXA-1, TLR4, NF-kappa Bp65, apoptosis index, and pulmonary permeability index were increased, whereas the levels of SOD, GSH-PX activity, and oxygenation index were decreased in rats with LIRI. Except for ANXA-1, these responses induced by LIRI were significantly inhibited by RvD1 treatment. In addition, LIRI-induced structure damages of lung tissues were also alleviated by RvD1 as shown by H&E staining and transmission electron microscopy. The results suggest that RvD1 may play an important role in protection of LIRI via inhibition of complement, immunoglobulin, and neutrophil activation; down-regulation of TLR4/NF-kappa B; and the expression of a variety of inflammatory factors.
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