Journal
INFLAMMATION
Volume 39, Issue 4, Pages 1582-1593Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-016-0394-3
Keywords
1,8-cineol; influenza A virus; inflammatory cytokines; viral pneumonia
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Funding
- Natural Science Foundation of China [81470186]
- Guangdong Provincial Natural Science Fund for Research grant (Team Project) [S2012030006598]
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1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1 beta, IL-6, TNF-alpha, and IFN-gamma in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.
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