4.5 Review

Bradykinin-target therapies in SARS-CoV-2 infection: current evidence and perspectives

Related references

Note: Only part of the references are listed.
Review Cell Biology

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

Masae Iwasaki et al.

Summary: The widespread occurrence of SARS-CoV-2 has led to a pandemic of COVID-19. The S spike protein of SARS-CoV-2 binds with ACE2, entering host cells and causing multi-organ damage by inducing inflammation.

INFLAMMATION (2021)

Article Medicine, Research & Experimental

Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial

Eli Mansour et al.

Summary: This study aims to explore the mechanism of increased bradykinin in the lungs of COVID-19 patients in developing pneumonia and respiratory failure, with three arms of randomized clinical trial designed for different treatment regimens. The results of the study may help alleviate lung inflammatory response in severe COVID-19 patients, positively impacting disease severity and mortality rates.

TRIALS (2021)

Article Endocrinology & Metabolism

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

Abraham J. Al-Ahmad et al.

Summary: The study revealed that bradykinin (BK), neurotensin (NT), and substance P (SP) can increase blood-brain barrier (BBB) permeability, with the combination of these peptides at sub-effective concentrations further enhancing their effects. Moreover, pretreatment with pharmacological blockers targeting specific receptors can neutralize the effects of BK, NT, and SP, suggesting potential therapeutic implications.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

Article Medicine, Research & Experimental

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

Simone R. Potje et al.

Summary: Plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption.

LIFE SCIENCES (2021)

Review Physiology

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19?

Vardan T. Karamyan

Summary: COVID-19, caused by SARS-CoV-2, is a global pandemic with significant socioeconomic impact. Inflammation is a major cause of complications, with studies focusing on pro-inflammatory cytokines and recently emerging peptide bradykinin as primary mechanisms. Besides bradykinin, substance P and neurotensin may also drive disease severity, and simultaneous inhibition of all three peptidergic systems could be therapeutically advantageous.

PHYSIOLOGICAL REPORTS (2021)

Review Peripheral Vascular Disease

Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update

Ashwin Kumar Shukla et al.

Summary: COVID-19 has affected more than 26 million individuals worldwide, with patients with diabetes mellitus or other major complications at high risk. ACE2 receptor plays a key role in the virus entry, leading to more severe disease outcomes. Treatment strategies for COVID-19 target either the virus-ACE2 interaction or the human immune system.

HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2021)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Editorial Material Anesthesiology

Angiotensin II for the Treatment of COVID-19-Related Vasodilatory Shock

Jonathan H. Chow et al.

ANESTHESIA AND ANALGESIA (2020)

Review Biochemistry & Molecular Biology

COVID-19 cytokine storm: The anger of inflammation

Mehdi Mahmudpour et al.

CYTOKINE (2020)

Article Chemistry, Medicinal

Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2

Soltan A. Ebrahimi

DRUG DEVELOPMENT RESEARCH (2020)

Article Biochemistry & Molecular Biology

A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications

Joseph A. Roche et al.

FASEB JOURNAL (2020)

Article Allergy

Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight?

Seyed-Mohammad Ghahestani et al.

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY (2020)

Article Reproductive Biology

Kallikrein-kinin system and oxidative stress in cisplatin-induced ovarian toxicity

Laura Silveira Ayres et al.

REPRODUCTIVE TOXICOLOGY (2020)

Article Medicine, Research & Experimental

What would Sergio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?

Lucas A. D. Nicolau et al.

MEDICAL HYPOTHESES (2020)

Review Pharmacology & Pharmacy

A comprehensive review on drug repositioning against coronavirus disease 2019 (COVID19)

Maryam Rameshrad et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

Article Pharmacology & Pharmacy

A lesson from a saboteur: High-MW kininogen impact in coronavirus-induced disease 2019

Chiara Colarusso et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Editorial Material Infectious Diseases

Hypertension prevalence in human coronavirus disease: the role of ACE system in infection spread and severity

Gaetano Ruocco et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Letter Medicine, General & Internal

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Frank L. van de Veerdonk et al.

JAMA NETWORK OPEN (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Review Allergy

Review of icatibant use in the Winnipeg Regional Health Authority

George Cai et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2020)

Review Immunology

The Immunology of Macrophage Activation Syndrome

Courtney B. Crayne et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Physiology

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

Chhinder P. Sodhi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception

Seung-In Choi et al.

BIOMOLECULES & THERAPEUTICS (2018)

Review Allergy

Bradykinin: Inflammatory Product of the Coagulation System

Zonne Hofman et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

Article Biotechnology & Applied Microbiology

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies

Naomi J. Wangler et al.

JOURNAL OF BIOTECHNOLOGY (2016)

Article Medicine, General & Internal

A Randomized Trial of Icatibant in ACE-Inhibitor-Induced Angioedema

Murat Bas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Cardiac & Cardiovascular Systems

Vascular endothelial dysfunction and pharmacological treatment

Jin Bo Su

WORLD JOURNAL OF CARDIOLOGY (2015)

Article Critical Care Medicine

Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

Marilee J. Wick et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Editorial Material Pharmacology & Pharmacy

Icatibant

Eline A. Dubois et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2010)

Review Immunology

Neutrophil serine proteases: specific regulators of inflammation

Christine T. N. Pham

NATURE REVIEWS IMMUNOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Products of angiotensin I hydrolysis by human cardiac enzymes potentiate Bradykinin

EG Erdös et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2002)

Letter Medicine, General & Internal

Bradykinin-mediated angioedema

J Nussberger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Biochemistry & Molecular Biology

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

C Vickers et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)