Genetic ancestry and racial differences in prostate tumours

A striking disproportionate burden of prostate cancer incidence and mortality exists between men of West African ancestry and men of European ancestry. Identifying distinct tumour genetic biomarkers and immunomodulating signals in patients with diverse genetic ancestry might reduce the disparities in prostate cancer prognosis, treatment outcomes and mortality in high-risk racial groups.

Automated summary

There is a significant disparity in prostate cancer incidence and mortality between men of West African ancestry and men of European ancestry. Identifying different tumor genetic markers and immunomodulating signals in patients with diverse genetic backgrounds may help reduce the disparities in prostate cancer prognosis, treatment outcomes, and mortality in high-risk racial groups.