Natural history of NAFLD: knowns and unknowns

Although nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, there is a paucity of good-quality data on its natural history and most studies to date have reported on retrospective data. Robust data are required to inform regulatory end points, trial design and models of care.

Automated summary

Nonalcoholic fatty liver disease is the most prevalent liver disease globally, but there is a lack of high-quality data on its natural history. More robust data are needed to inform regulatory end points, trial design, and models of care.