4.6 Review

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule

Hongwei Si et al.

Summary: Epicatechin is a flavonoid found in various foods like cocoa and tea, and has been reported to promote the health and survival of old mice. However, the anti-aging mechanism of EC is not fully understood, which hinders its potential application in extending healthy lifespan in humans.

CURRENT MEDICINAL CHEMISTRY (2021)

Article Neurosciences

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

Jasvinder Singh Bhatti et al.

Summary: The study found that SS31 treatment in diabetic mice could reduce mitochondrial dysfunction, restore mitochondrial function, lower lipid peroxidation, and increase ATP production, serving as a potential protective measure.

MOLECULAR NEUROBIOLOGY (2021)

Review Endocrinology & Metabolism

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes

Sophie Hallakou-Bozec et al.

Summary: Imeglimin is a novel oral agent for treating type 2 diabetes, with dual effects of enhancing insulin secretion and action while correcting mitochondrial dysfunction. It has shown promising results in reducing blood glucose levels and preserving beta-cell mass, targeting the defective cellular energy metabolism underlying T2D.

DIABETES OBESITY & METABOLISM (2021)

Article Multidisciplinary Sciences

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease

Gerald J. Shami et al.

Summary: Giant mitochondria exhibit peculiar shape and large size in hepatic parenchymal cells, typically associated with cellular adversity, particularly in non-alcoholic fatty liver disease. This liver disease is the most prevalent in lipid dysmetabolism, where mitochondrial dysfunction plays a crucial role.

SCIENTIFIC REPORTS (2021)

Article Immunology

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis

Sylvia Torres-Odio et al.

Summary: CLPP deficiency results in abnormal immune system responses in mice, leading to increased resistance to RNA and DNA virus infections. The instability and packaging alterations of mitochondrial DNA caused by CLPP deficiency drive the IFN-I signaling pathway.

JOURNAL OF IMMUNOLOGY (2021)

Article Cell Biology

Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice

Jasvinder Singh Bhatti et al.

Summary: This study investigated the molecular alterations induced by hyperglycemia in the mitochondria of diabetic mice and explored the possible ameliorative role of the mitochondria-targeted small peptide, SS31. The findings showed that diabetic mice exhibited mitochondrial dysfunction, characterized by increased H2O2 production, lipid peroxidation, and decreased ATP production, while SS31 treatment significantly reduced these abnormalities and restored mitochondrial functions.

MITOCHONDRION (2021)

Review Pharmacology & Pharmacy

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

Ricardo P. Garay

Summary: Research has shown the potential of several drugs in clinical trials to prolong lifespan, including metformin, acarbose, and rapamycin. Additionally, vitamin D supplementation is also being investigated for its potential to reduce all-cause mortality.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

Article Multidisciplinary Sciences

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

Baback Roshanravan et al.

Summary: The study showed that ELAM can rapidly and reversibly increase mitochondrial capacity after a single dose, but did not significantly affect muscle fatigue resistance.

PLOS ONE (2021)

Review Cell Biology

The road ahead for health and lifespan interventions

Marta Gonzalez-Freire et al.

AGEING RESEARCH REVIEWS (2020)

Article Multidisciplinary Sciences

Moderation of mitochondrial respiration mitigates metabolic syndrome of aging

Mojdeh S. Tavallaie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Endocrinology & Metabolism

Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy

Sergio Davinelli et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

Article Multidisciplinary Sciences

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Stephanie J. Alexopoulos et al.

NATURE COMMUNICATIONS (2020)

Review Endocrinology & Metabolism

Metformin and Its Benefits for Various Diseases

Ziquan Lv et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Cell Biology

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Guo Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD plus Metabolism

Weiqi Hong et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Geriatrics & Gerontology

Nicotinamide riboside ? A missing piece in the puzzle of exercise therapy for older adults?

Carlo Custodero et al.

EXPERIMENTAL GERONTOLOGY (2020)

Review Immunology

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Tao Gong et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Cell Biology

The proteostasis network and its decline in ageing

Mark S. Hipp et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Naohide Kanemoto et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Mitochondrial quality control as a key determinant of cell survival

Lucia Sedlackova et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Metabolic features and regulation in cell senescence

So Mee Kwon et al.

BMB REPORTS (2019)

Article Biology

Identification of 12 genetic loci associated with human healthspan

Aleksandr Zenin et al.

COMMUNICATIONS BIOLOGY (2019)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Toxicology

Lon in maintaining mitochondrial and endoplasmic reticulum homeostasis

Jieyeqi Yang et al.

ARCHIVES OF TOXICOLOGY (2018)

Review Cell Biology

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Luis Rajman et al.

CELL METABOLISM (2018)

Review Cell Biology

Defective Autophagy in Atherosclerosis: To Die or to Senesce?

Mandy O. J. Grootaert et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Multidisciplinary Sciences

Molecular structural diversity of mitochondrial cardiolipins

Gregor Oemer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

Cristiana Porcu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome

Stephanie E. Siegmund et al.

HUMAN MOLECULAR GENETICS (2017)

Article Gastroenterology & Hepatology

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Karim Gariani et al.

JOURNAL OF HEPATOLOGY (2017)

Review Immunology

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

Aakanksha Jain et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Significance of Resveratrol in Clinical Management of Chronic Diseases

Awais Wahab et al.

MOLECULES (2017)

Review Cell Biology

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Arnab Ray Chaudhuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Cellular senescence drives age-dependent hepatic steatosis

Mikolaj Ogrodnik et al.

NATURE COMMUNICATIONS (2017)

Article Endocrinology & Metabolism

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects With Prediabetes and Type 2 Diabetes Mellitus

Shipra Bhansali et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

Review Geriatrics & Gerontology

The Oxygen Paradox, the French Paradox, and age-related diseases

Joanna M. S. Davies et al.

GEROSCIENCE (2017)

Review Biochemistry & Molecular Biology

The Origin and Diversification of Mitochondria

Andrew J. Roger et al.

CURRENT BIOLOGY (2017)

Review Immunology

Mitochondrial DNA in innate immune responses and inflammatory pathology

A. Phillip West et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Review Cell Biology

Mammalian Mitochondria and Aging: An Update

Timo E. S. Kauppila et al.

CELL METABOLISM (2017)

Article Endocrinology & Metabolism

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity

Rainey E. Patterson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)

Review Biochemistry & Molecular Biology

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

Timothy M. Griffin et al.

BIOCHIMIE (2016)

Review Pharmacology & Pharmacy

Targeting Mitochondria in Cardiovascular Diseases

Filomena S. G. Silva et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

Article Medicine, Research & Experimental

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Irma Garcia-Martinez et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Neurosciences

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

Natalia S. Morsci et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Neurosciences

Calorie restriction as an intervention in ageing

Guillermo Lopez-Lluch et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Review Gastroenterology & Hepatology

Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

Luca Valenti et al.

LIVER INTERNATIONAL (2016)

Article Biochemistry & Molecular Biology

Urolithin A induces mitophagy and prolongs lifespan in C-elegans and increases muscle function in rodents

Dongryeol Ryu et al.

NATURE MEDICINE (2016)

Review Cell Biology

Nuclear DNA damage signalling to mitochondria in ageing

Evandro Fei Fang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Erin Quan Toyama et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Melissa F. Brereton et al.

NATURE COMMUNICATIONS (2016)

Review Immunology

Resolution of inflammation: what Controls its Onset?

Michelle A. Sugimoto et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Samuel A. J. Trammell et al.

SCIENTIFIC REPORTS (2016)

Article Genetics & Heredity

Maternal smoking during pregnancy is associated with mitochondrial DNA methylation

David A. Armstrong et al.

ENVIRONMENTAL EPIGENETICS (2016)

Review Cell Biology

Mitochondrial proteases and protein quality control in ageing and longevity

Marie-Paule Hamon et al.

AGEING RESEARCH REVIEWS (2015)

Review Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

Sky W. Brubaker et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Review Biochemistry & Molecular Biology

Mitochondria: Are they causal players in cellular senescence?

Clara Correia-Melo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Review Biochemistry & Molecular Biology

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Luigi Fontana et al.

Editorial Material Cell Biology

Evolution of Mitochondria as Signaling Organelles

Navdeep S. Chandel

CELL METABOLISM (2015)

Article Endocrinology & Metabolism

p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

Stefano Ciciliot et al.

DIABETOLOGIA (2015)

Review Medicine, Research & Experimental

Mitochondrial disease in adults: what's old and what's new?

Patrick F. Chinnery

EMBO MOLECULAR MEDICINE (2015)

Article Biochemistry & Molecular Biology

Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors A NEW MECHANISM FOR SENSING PATHOGENS

Bernd Bufe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Coordination of mitophagy and mitochondrial biogenesis during ageing in C-elegans

Konstantinos Palikaras et al.

NATURE (2015)

Article Multidisciplinary Sciences

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

Christal D. Sohl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Rachel J. Perry et al.

SCIENCE (2015)

Article Oncology

Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease

Andrea A. Baccarelli et al.

CLINICAL EPIGENETICS (2015)

Article Gerontology

Lifespan and Healthspan: Past, Present, and Promise

Eileen M. Crimmins

GERONTOLOGIST (2015)

Article Ophthalmology

Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy

Manish Mishra et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease: The diagnosis and management

Shehab M. Abd El-Kader et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Cardiac & Cardiovascular Systems

p66Shc-induced redox changes drive endothelial insulin resistance

Francesco Paneni et al.

ATHEROSCLEROSIS (2014)

Editorial Material Cell Biology

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

Morten Scheibye-Knudsen et al.

AUTOPHAGY (2014)

Editorial Material Biochemistry & Molecular Biology

Geroscience: Linking Aging to Chronic Disease

Brian K. Kennedy et al.

Article Biochemistry & Molecular Biology

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Evandro Fei Fang et al.

Article Cell Biology

A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

Morten Scheibye-Knudsen et al.

CELL METABOLISM (2014)

Review Biochemistry & Molecular Biology

Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases

Shun Nagashima et al.

JOURNAL OF BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes

Soo Jin Yang et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Hanlin Tao et al.

NATURE MEDICINE (2014)

Review Cell Biology

Succinate: a metabolic signal inflammation

Evanna Mills et al.

TRENDS IN CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

Maternally transmitted mitochondrial DNA mutations can reduce lifespan

Jaime M. Ross et al.

SCIENTIFIC REPORTS (2014)

Article Medicine, General & Internal

Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study

Rachel Cooper et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Review Biochemistry & Molecular Biology

Mitochondrial Fatty Acid Oxidation in Obesity

Dolors Serra et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Cardiac & Cardiovascular Systems

Changes of mitochondria in atherosclerosis: Possible determinant in the pathogenesis of the disease

Igor A. Sobenin et al.

ATHEROSCLEROSIS (2013)

Review Biochemistry & Molecular Biology

Chaperone-protease networks in mitochondrial protein homeostasis

Wolfgang Voos

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Biochemistry & Molecular Biology

Oxidative stress and vascular inflammation in aging

Mariam El Assar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Medicine, Research & Experimental

Mitochondrial DNA mutations and essential hypertension

Yu Ding et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Review Medicine, Research & Experimental

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tamara Tchkonia et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Jaime M. Ross et al.

NATURE (2013)

Article Multidisciplinary Sciences

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill et al.

NATURE (2013)

Article Multidisciplinary Sciences

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Basil P. Hubbard et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

Simon C. Johnson et al.

SCIENCE (2013)

Article Endocrinology & Metabolism

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

Hongliang Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Hematology

Mitochondrial dysfunction in ataxia-telangiectasia

Yasmine A. Valentin-Vega et al.

BLOOD (2012)

Article Biochemistry & Molecular Biology

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

Santhosh Satapati et al.

JOURNAL OF LIPID RESEARCH (2012)

Review Cell Biology

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Bryan A. Gibson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Rheumatology

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

Helena Erlandsson Harris et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Article Multidisciplinary Sciences

Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro

Maria F. Lodeiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Human mortality improvement in evolutionary context

Oskar Burger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Superoxide dismutase is dispensable for normal animal lifespan

Jeremy Michael Van Raamsdonk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

Agnieszka A. Kendrick et al.

BIOCHEMICAL JOURNAL (2011)

Article Cell Biology

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

Carlo Viscomi et al.

CELL METABOLISM (2011)

Review Biochemistry & Molecular Biology

Calorie restriction and prevention of age-associated chronic disease

Daniela Omodei et al.

FEBS LETTERS (2011)

Review Endocrinology & Metabolism

Preservation of β-Cell Function: The Key to Diabetes Prevention

Ralph A. DeFronzo et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Review Immunology

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

Edwina Naik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Neurosciences

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

Barry A. Chestnut et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Endocrinology & Metabolism

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

Vittoria Infantino et al.

MOLECULAR GENETICS AND METABOLISM (2011)

Article Nutrition & Dietetics

T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects

Vincenzo Ostilio Palmieri et al.

NUTRITION (2011)

Article Multidisciplinary Sciences

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

Lisa S. Shock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and lipotoxicity

Patrick Schrauwen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

Review Biochemistry & Molecular Biology

AMP-activated protein kinase and its downstream transcriptional pathways

Carles Canto et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Review Endocrinology & Metabolism

The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

Ines Pagel-Langenickel et al.

ENDOCRINE REVIEWS (2010)

Article Allergy

Overview of the immune response

David D. Chaplin

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Article Medicine, Research & Experimental

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Shinji Kume et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Joao F. Passos et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

Article Multidisciplinary Sciences

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Jaime M. Ross et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Multidisciplinary Sciences

Extending Healthy Life Span-From Yeast to Humans

Luigi Fontana et al.

SCIENCE (2010)

Review Biochemistry & Molecular Biology

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Eric Verdin et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Immunology

Coronary Aging in HIV-Infected Patients

Giovanni Guaraldi et al.

CLINICAL INFECTIOUS DISEASES (2009)

Article Endocrinology & Metabolism

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

M. J. MacDonald et al.

DIABETOLOGIA (2009)

Article Public, Environmental & Occupational Health

Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations?

Raj S. Bhopal et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2009)

Article Geriatrics & Gerontology

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

Reyhan Westbrook et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

Article Cell Biology

Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy

Nao Hosokawa et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Multidisciplinary Sciences

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Michael R. Elliott et al.

NATURE (2009)

Review Medicine, General & Internal

MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer

Jan H. J. Hoeijmakers

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Genetics & Heredity

Mitochondrial DNA mutations and aging: devils in the details?

Konstantin Khrapko et al.

TRENDS IN GENETICS (2009)

Article Cell Biology

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

Camille C. Caldeira da Silva et al.

AGING CELL (2008)

Review Biochemistry & Molecular Biology

Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities

Shane R. Thomas et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

Article Biochemistry & Molecular Biology

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

Ina Berniakovich et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Bong-Hyun Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex

John T. Cunningham et al.

NATURE (2007)

Article Multidisciplinary Sciences

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

Nidhi Ahuja et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38

Xiaochun Bai et al.

SCIENCE (2007)

Article Oncology

Somatic mtDNA mutations cause progressive hearing loss in the mouse

Xianzhi Niu et al.

EXPERIMENTAL CELL RESEARCH (2007)

Article Geriatrics & Gerontology

HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty

Loic Desquilbet et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)

Article Multidisciplinary Sciences

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Sibylle Jaeger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases

Andrew M. James et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Joao F. Passos et al.

PLOS BIOLOGY (2007)

Article Genetics & Heredity

Mitochondrial point mutations do not limit the natural lifespan of mice

Marc Vermulst et al.

NATURE GENETICS (2007)

Article Multidisciplinary Sciences

Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress

Giovanni G. Camici et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Genetics & Heredity

Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians

Noriyuki Fuku et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Medicine, General & Internal

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

Anthony E. Civitarese et al.

PLOS MEDICINE (2007)

Article Endocrinology & Metabolism

Women with mitochondrial haplogroup N9a are protected against metabolic syndrome

Masashi Tanaka et al.

DIABETES (2007)

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur et al.

NATURE (2006)

Article Cardiac & Cardiovascular Systems

Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene

Marcello Rota et al.

CIRCULATION RESEARCH (2006)

Review Biochemistry & Molecular Biology

Pathogen recognition and innate immunity

S Akira et al.

Review Medicine, General & Internal

Ageing and vascular ageing

B. Jani et al.

POSTGRADUATE MEDICAL JOURNAL (2006)

Article Biochemistry & Molecular Biology

Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX

SG Kang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Medicine, General & Internal

Obesity

DW Haslam et al.

LANCET (2005)

Review Gastroenterology & Hepatology

NASH: a mitochondrial disease

D Pessayre et al.

JOURNAL OF HEPATOLOGY (2005)

Article Multidisciplinary Sciences

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

NATURE (2005)

Article Endocrinology & Metabolism

Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells:: Relationship to oxidative stress

E Pagnin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Article Cardiac & Cardiovascular Systems

Deletion of p66shc gene protects against age-related endothelial dysfunction

P Francia et al.

CIRCULATION (2004)

Article Multidisciplinary Sciences

Premature ageing in mice expressing defective mitochondrial DNA polymerase

A Trifunovic et al.

NATURE (2004)

Article Multidisciplinary Sciences

Mitochondrial dysfunction in the elderly: Possible role in insulin resistance

KF Petersen et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Extended longevity in mice lacking the insulin receptor in adipose tissue

M Blüher et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress

K Kirby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

HH Zong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Endocrinology & Metabolism

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

DE Kelley et al.

DIABETES (2002)

Article Medicine, General & Internal

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

WC Knowler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Review Geriatrics & Gerontology

Andropause: Clinical implications of the decline in serum testosterone levels with aging in men

AM Matsumoto

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2002)

Article Geriatrics & Gerontology

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

MD Brand

EXPERIMENTAL GERONTOLOGY (2000)

Article Biochemistry & Molecular Biology

Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue

M Rossmeisl et al.

FASEB JOURNAL (2000)