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Gustavo A. Santos et al.
PLOS ONE (2013)
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Jurre J. Kamphorst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
E. L. Pearce et al.
SCIENCE (2013)
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Leah Eissing et al.
NATURE COMMUNICATIONS (2013)
On the Catalytic Mechanism of Human ATP Citrate Lyase
Fan Fan et al.
BIOCHEMISTRY (2012)
Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
Makoto Kamata et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
Makoto Kamata et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
William A. Freed-Pastor et al.
CELL (2012)
Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity
Irian J. Lodhi et al.
CELL METABOLISM (2012)
Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice
S. Glund et al.
DIABETOLOGIA (2012)
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.
Mohammad Abolhassani et al.
INVESTIGATIONAL NEW DRUGS (2012)
Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins
Yun Jeong Kim et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)
ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Nousheen Zaidi et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Mark A. Herman et al.
NATURE (2012)
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
Fabian V. Filipp et al.
PIGMENT CELL & MELANOMA RESEARCH (2012)
Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)
Puspa R. Pandey et al.
Recent Patents on Anti-Cancer Drug Discovery (2012)
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors
Tohru Yamashita et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Deep sequencing reveals 50 novel genes for recessive cognitive disorders
Hossein Najmabadi et al.
NATURE (2011)
Regulation of Cholesterol and Fatty Acid Synthesis
Jin Ye et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
The Yeast Mitochondrial Citrate Transport Protein MOLECULAR DETERMINANTS OF ITS SUBSTRATE SPECIFICITY
Sreevidya Aluvila et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis
Jochen G. Schneider et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor
Sreevidya Aluvila et al.
MOLECULAR PHARMACOLOGY (2010)
Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells
Daniel Hess et al.
PLOS ONE (2010)
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells
Quanri Jin et al.
BREAST CANCER RESEARCH (2010)
(4-Piperidinyl)-piperazine: A new platform for acetyl-CoA carboxylase inhibitors
Tomomichi Chonan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet
M. Schreurs et al.
DIABETES OBESITY & METABOLISM (2009)
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans
R. Roberts et al.
DIABETOLOGIA (2009)
Abrogation of Hepatic ATP-Citrate Lyase Protects Against Fatty Liver and Ameliorates Hyperglycemia in Leptin Receptor-Deficient Mice
Qiong Wang et al.
HEPATOLOGY (2009)
Mitochondrial Fatty Acid Synthesis Type II: More than Just Fatty Acids
J. Kalervo Hiltunen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Brief Report: Functional Brown Adipose Tissue in Healthy Adults.
Kirsi A. Virtanen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues
Jianqiang Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen et al.
SCIENCE (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford et al.
NATURE REVIEWS CANCER (2009)
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
Nobito Higuchi et al.
HEPATOLOGY RESEARCH (2008)
Chronic suppression of Acetyl-CoA carboxylase 1 in β-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism
Sarah M. Ronnebaum et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
Joshua Munger et al.
NATURE BIOTECHNOLOGY (2008)
The crystal structure of a mammalian fatty acid synthase
Timm Maier et al.
SCIENCE (2008)
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands
Feng Cheng et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor α pathway
Jeffrey F. Waring et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats
Mohammad Asghar et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells
Tik-Shun Ho et al.
BIOMEDICINE & PHARMACOTHERAPY (2007)
Brain fatty acid synthase activates PPARα to maintain energy homeostasis
Manu V. Chakravarthy et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein
Chunlong Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors
James J. Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-CoA carboxylase inhibitors -: Improvement of cardiovascular and neurological liabilities via structural modifications
Yu Gui Gu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The liver X receptor (LXR) and hepatic lipogenesis - The carbohydrate-response element-binding protein is a target gene of LXR
Ji-Young Cha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The role of hypothalamic malonyl-CoA in energy homeostasis
Michael J. Wolfgang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
Jamie W. Joseph et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors
Yu Gui Gu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis
Jianqiang Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Acetyl-CoA carboxylase α is essential to breast cancer cell survival
Veronique Chajes et al.
CANCER RESEARCH (2006)
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
DB Savage et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Fatty acid synthase hyperactivation in human colorectal cancer: Relationship with tumor side and sex
Maria Notarnicola et al.
ONCOLOGY (2006)
KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
YS Chang et al.
JOURNAL OF LIPID RESEARCH (2005)
ATP citrate lyase inhibition can suppress tumor cell growth
G Hatzivassiliou et al.
CANCER CELL (2005)
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
L Abu-Elheiga et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
L Tong
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
New hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis
MV Chakravarthy et al.
CELL METABOLISM (2005)
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
R Roduit et al.
DIABETES (2004)
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
SJ Kridel et al.
CANCER RESEARCH (2004)
ATP-citrate lyase deficiency in the mouse
AP Beigneux et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex with CP-640186
HL Zhang et al.
STRUCTURE (2004)
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme a carboxylase by soraphen A, a macrocyclic polyketide natural product
Y Shen et al.
MOLECULAR CELL (2004)
Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass
JN Thupari et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome
CT Cramer et al.
JOURNAL OF LIPID RESEARCH (2004)
Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss
HG Preuss et al.
DIABETES OBESITY & METABOLISM (2004)
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals
HJ Harwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structural and functional organization of the animal fatty acid synthase
S Smith et al.
PROGRESS IN LIPID RESEARCH (2003)
Fatty acid synthesis is essential in embryonic development:: Fatty acid synthase null mutants and most of the heterozygotes die in utero
SS Chirala et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem
S Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase
HL Zhang et al.
SCIENCE (2003)
Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis
BL Fatland et al.
PLANT PHYSIOLOGY (2002)
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
DC Berwick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
YA Yang et al.
EXPERIMENTAL CELL RESEARCH (2002)
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
JN Thupari et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats
LL Atkinson et al.
DIABETES (2002)
Functional neurogenesis in the adult hippocampus
H van Praag et al.
NATURE (2002)
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides
T Shimokawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting
H Makimura et al.
DIABETES (2001)
Radicicol binds and inhibits mammalian ATP citrate lyase
SW Ki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
JV Swinnen et al.
ONCOGENE (2000)
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
TM Loftus et al.
SCIENCE (2000)
Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity.: Allosteric activation of ATP:citrate lyase by phosphorylated sugars
IA Potapova et al.
BIOCHEMISTRY (2000)
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