4.7 Article

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen et al.

Summary: The development of an amphiphilic dendrimer for efficient siRNA delivery to various primary immune cells represents a significant advancement in immunological research. This protocol includes dendrimer synthesis, immune cell preparation, siRNA delivery, and functional assays, with the dendrimer-mediated siRNA delivery outperforming standard electroporation techniques.

NATURE PROTOCOLS (2021)

Article Chemistry, Multidisciplinary

Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy

Xiangang Huang et al.

Summary: This study presents a novel approach using an intercalation-driven siRNA nanogels (NG) as a delivery vehicle, which demonstrates good stability and efficient intracellular delivery for cancer therapy.

NANO LETTERS (2021)

Article Chemistry, Multidisciplinary

Insights from nanotechnology in COVID-19 treatment

Zhongmin Tang et al.

Summary: In response to the COVID-19 pandemic, nanotechnology plays a significant role in antiviral research, particularly in drug and vaccine delivery, interference in the virus life cycle, and pneumonia treatment.

NANO TODAY (2021)

Article Multidisciplinary Sciences

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Zijun Wang et al.

Summary: Volunteers who received the Moderna or Pfizer-BioNTech vaccine showed high levels of antibodies and memory B cell responses against SARS-CoV-2, with activity similar to individuals who had recovered from natural infection. However, their efficacy against specific SARS-CoV-2 variants was reduced, indicating a potential need for periodic updates to mRNA vaccines to maintain clinical efficacy.

NATURE (2021)

Article Chemistry, Physical

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing

Shuai Liu et al.

Summary: The study successfully delivered mRNA or single-guide RNA for gene editing in vivo using combinatorially synthesized ionizable phospholipids. Optimized iPhos lipids can change shapes in endosomal acidic environments to facilitate the release of gene editing materials. When working synergistically with helper lipids, iPhos lipids can achieve targeted delivery to specific organs.

NATURE MATERIALS (2021)

Letter Medicine, General & Internal

Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine

Todd Bradley et al.

Summary: A small study found that antibody responses significantly increased in healthcare workers after receiving a single dose of the SARS-CoV-2 vaccine, including antibodies to spike protein subunits S1 and S2, as well as the receptor-binding domain.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Chemistry, Multidisciplinary

Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

Hannah J. Vaughan et al.

ADVANCED MATERIALS (2020)

Review Cardiac & Cardiovascular Systems

Transcriptional and epigenetic regulation of macrophages in atherosclerosis

Tatyana Kuznetsova et al.

NATURE REVIEWS CARDIOLOGY (2020)

Review Chemistry, Multidisciplinary

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Yue Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Nanoscience & Nanotechnology

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing

Qiang Cheng et al.

NATURE NANOTECHNOLOGY (2020)

Review Chemistry, Multidisciplinary

Stimulus-responsive sequential release systems for drug and gene delivery

Sepideh Ahmadi et al.

NANO TODAY (2020)

Review Nanoscience & Nanotechnology

A materials-science perspective on tackling COVID-19

Zhongmin Tang et al.

NATURE REVIEWS MATERIALS (2020)

Article Multidisciplinary Sciences

Blood-brain barrier-penetrating siRNA nanomedicine for Alzheimer's disease therapy

Yutong Zhou et al.

SCIENCE ADVANCES (2020)

Article Chemistry, Multidisciplinary

Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency

Hien Bao Dieu Thai et al.

ACS CENTRAL SCIENCE (2020)

Review Immunology

Efferocytosis in health and disease

Amanda C. Doran et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Chemistry, Multidisciplinary

DNA Nanotechnology-Enabled Drug Delivery Systems

Qinqin Hu et al.

CHEMICAL REVIEWS (2019)

Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

Article Hematology

Nanoparticle Therapy for Vascular Diseases

Alyssa M. Flores et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

Jayesh A. Kulkarni et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Nanoscience & Nanotechnology

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

Colleen N. Loynachan et al.

NATURE NANOTECHNOLOGY (2019)

Review Engineering, Biomedical

RNA delivery biomaterials for the treatment of genetic and rare diseases

Weiyu Zhao et al.

BIOMATERIALS (2019)

Article Engineering, Biomedical

DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides

Qinqin Hu et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Nanoscience & Nanotechnology

Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice

Hua Pan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Article Engineering, Biomedical

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

Mohammad Ariful Islam et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Review Biochemistry & Molecular Biology

Considering sex as a biological variable in preclinical research

Leah R. Miller et al.

FASEB JOURNAL (2017)

Article Medicine, Research & Experimental

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

Amanda C. Doran et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Medicine, Research & Experimental

Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo

Xi Zhu et al.

THERANOSTICS (2017)

Article Chemistry, Multidisciplinary

Systemic Delivery of Bc12-Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth

Mohammad Aminur Rahman et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Optimized DNA Nanosuitcases for Encapsulation and Conditional Release of siRNA

Katherine E. Bujold et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Article Nanoscience & Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Susanne Schoettler et al.

NATURE NANOTECHNOLOGY (2016)

Article Biotechnology & Applied Microbiology

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Anders Wittrup et al.

NATURE BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment

Xi Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Immunology

Macrophage activation in human diseases

Joachim L. Schultze et al.

SEMINARS IN IMMUNOLOGY (2015)

Article Nanoscience & Nanotechnology

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

James E. Dahlman et al.

NATURE NANOTECHNOLOGY (2014)

Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

Article Multidisciplinary Sciences

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Kathryn A. Whitehead et al.

NATURE COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Jerome Gilleron et al.

NATURE BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Gaurav Sahay et al.

NATURE BIOTECHNOLOGY (2013)

Review Chemistry, Physical

Delivery materials for siRNA therapeutics

Rosemary Kanasty et al.

NATURE MATERIALS (2013)

Article Multidisciplinary Sciences

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

Xiaoyang Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

An influenza virus-inspired polymer system for the timed release of siRNA

Nghia P. Truong et al.

NATURE COMMUNICATIONS (2013)

Article Medicine, Research & Experimental

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Barbara L. Mui et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

Article Nanoscience & Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

Hyukjin Lee et al.

NATURE NANOTECHNOLOGY (2012)

Review Cell Biology

The functions and regulation of the PTEN tumour suppressor

Min Sup Song et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Chemistry, Multidisciplinary

Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

Jinjun Shi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Review Biochemistry & Molecular Biology

Macrophages in the Pathogenesis of Atherosclerosis

Kathryn J. Moore et al.

Article Biochemistry & Molecular Biology

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

Marija Tadin-Strapps et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biotechnology & Applied Microbiology

Therapeutic siRNA silencing in inflammatory monocytes in mice

Florian Leuschner et al.

NATURE BIOTECHNOLOGY (2011)

Review Genetics & Heredity

Current prospects for RNA interference-based therapies

Beverly L. Davidson et al.

NATURE REVIEWS GENETICS (2011)

Article Hematology

Concept of Vulnerable/Unstable Plaque

Aloke V. Finn et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Biotechnology & Applied Microbiology

Rational design of cationic lipids for siRNA delivery

Sean C. Semple et al.

NATURE BIOTECHNOLOGY (2010)

Review Biotechnology & Applied Microbiology

Strategies in the design of nanoparticles for therapeutic applications

Robby A. Petros et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Multidisciplinary Sciences

Lipid-like materials for low-dose, in vivo gene silencing

Kevin T. Love et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Multidisciplinary Sciences

The promises and pitfalls of RNA-interference-based therapeutics

Daniela Castanotto et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

Knocking down barriers: advances in siRNA delivery

Kathryn A. Whitehead et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biochemistry & Molecular Biology

RNA major groove modifications improve siRNA stability and biological activity

Montserrat Terrazas et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Biochemistry & Molecular Biology

Targeted cationic poly(D,L-lactic-co-glycolic acid) nanoparticles for gene delivery to cultured cells

Sonsoles Diez et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2009)

Article Multidisciplinary Sciences

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Maria Frank-Kamenetsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs

Mouldy Sioud et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Multidisciplinary Sciences

RNAi-mediated gene silencing in non-human primates

TS Zimmermann et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Chemical modification of siRNAs to improve serum stability without loss of efficacy

S Choung et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)