Journal
NATURE NEUROSCIENCE
Volume 25, Issue 2, Pages 136-138Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-021-00998-z
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Funding
- Canadian Institutes for Health Research (CIHR) [PJT-378765]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-06657]
- Canada Foundation [37267]
- Tier 2 Canada Research Chair in Brain Regulation of Metabolism at the University of Alberta
- Diabetes Canada Scholar Award [SC-5-16-5060-JY]
- National Institutes of Health [NIH-1R01DK121804]
- United States Department of Agriculture (USDA)-National Institute of Food and Agriculture (NIFA) [2019-67017-29252]
- CIHR Foundation Grant [FDN-143204]
- Tier 1 Canada Research Chair in Diabetes and Obesity at the Toronto General Hospital Research Institute
- University of Toronto
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A recent study found that the duodenum can distinguish between sugar and sweeteners, but the specific cells involved in this process remain unknown. Researchers engineered a flexible optic fiber for optogenetic manipulation of gut cells in mice, and found that silencing CCK cells in the duodenum reduced the preference for sugar and increased the intake of sweeteners. This study suggests that gut optogenetics may provide insights into how the gut-brain axis regulates feeding and glucose homeostasis.
The duodenum distinguishes between sugar and sweeteners, but the cells involved in this process remain elusive. Buchanan and colleagues engineered a flexible optic fiber for optogenetic manipulation of gut cells in mice. Silencing duodenal CCK cells reduced the preference for sugar over sweetener intake. Gut optogenetics may elucidate how the gut-brain axis regulates feeding and glucose homeostasis.
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