Journal
NATURE NEUROSCIENCE
Volume 25, Issue 1, Pages 4-6Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-021-00968-5
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Funding
- US National Institute of Mental Health [R01MH084894, R01MH111940]
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This study successfully designed a new drug with dual effects of antipsychotic and antidepressant by combining X-ray crystallography, medicinal chemistry, and behavioral pharmacology.
The structural basis for the clinical and side effects of antipsychotic drugs has not been resolved. A new study combined X-ray crystallography with medicinal chemistry and behavioral pharmacology to design a new dopamine D-2 receptor partial agonist that, in mice, shows not only antipsychotic-like activity but also 5-HT1A-receptor-dependent antidepressant-like effects.
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