4.8 Article

Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

Nick Andrews et al.

Summary: A study conducted in England showed that vaccines against SARS-CoV-2 provide high protection against hospitalization and death from Covid-19 at 20 weeks or more after vaccination. However, the effectiveness of the vaccines decreases over time, especially in individuals aged 65 and older and those with underlying risk factors.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Infectious Diseases

SARS-CoV-2 infection and transmission in educational settings: a prospective, cross-sectional analysis of infection clusters and outbreaks in England

Sharif A. Ismail et al.

Summary: This study estimated the rate of SARS-CoV-2 infection and outbreaks among staff and students in educational settings in England during the summer half-term of 2020, finding that infections and outbreaks were uncommon in educational settings, but strongly associated with regional COVID-19 incidence. The results emphasize the importance of controlling community transmission to protect educational settings, with interventions focusing on reducing transmission among staff.

LANCET INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar

Laith J. Abu-Raddad et al.

Summary: This study aimed to assess the protection against breakthrough infection with SARS-CoV-2 after mRNA vaccination, comparing individuals with and without prior infection. The findings showed that individuals with prior SARS-CoV-2 infection had a significantly lower risk for breakthrough infection, indicating a potential benefit of natural immunity in vaccine protection.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

Noam Barda et al.

Summary: A study using data from Israel's largest health-care organization showed that a third dose of the BNT162b2 mRNA vaccine is effective in preventing individuals from severe COVID-19-related outcomes, compared to receiving only two doses at least 5 months ago. The effectiveness of the third dose in preventing hospital admission was 93%, severe disease 92%, and COVID-19-related death 81%.

LANCET (2021)

Article Biochemistry & Molecular Biology

Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Koen B. Pouwels et al.

Summary: A large, community-based study in the United Kingdom indicates that the effectiveness of BNT162b2 and ChAdOx1 vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant. Although the effectiveness of two doses is at least as great as protection afforded by prior natural infection, there are significant differences in the dynamics of immunity after the second dose between BNT162b2 and ChAdOx1.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Waning Immunity after the BNT162b2 Vaccine in Israel

Yair Goldberg et al.

Summary: The immunity against the delta variant of SARS-CoV-2 waned in all age groups in Israel a few months after receiving the second dose of the vaccine, leading to an increase in infection and severe cases.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

Ronen Arbel et al.

Summary: Among 843,208 participants in Israel aged 50 years or older who had received two doses of the BNT162b2 vaccine at least 5 months earlier, those who received a booster had 90% lower mortality due to Covid-19 than those who did not receive a booster during the 54-day study period.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine

Barak Mizrahi et al.

Summary: The study indicates preliminary evidence of waning vaccine effectiveness of BNT162b2 among all age groups above 16, with a higher incidence of infection in those vaccinated earlier in 2021. Further investigation into long-term protection against different strains is warranted.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England

Gayatri Amirthalingam et al.

Summary: The UK extended the interval between COVID-19 vaccine doses to 12 weeks, leading to higher antibody levels and estimated greater vaccine effectiveness. This study highlights the importance of an extended vaccine schedule in enhancing protection against COVID-19.

NATURE COMMUNICATIONS (2021)

Article Medicine, General & Internal

Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study

Ariel Israel et al.

Summary: In this study, it was found that the risk of COVID-19 infection gradually increased in adults who received their second dose of the BNT162b2 mRNA vaccine after at least 90 days, based on electronic health records.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Medicine, General & Internal

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

Eleftheria Vasileiou et al.

Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.

LANCET (2021)

Article Medicine, General & Internal

Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study

Jamie Lopez Bernal et al.

Summary: This study estimated the real-world effectiveness of Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed COVID-19 symptoms, hospital admissions, and deaths. The vaccines showed significant reduction in symptomatic COVID-19 among older adults and further protection against severe disease. Both vaccines demonstrated similar effects and protection was maintained for over 6 weeks.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Infectious Diseases

Effectiveness of BNT162b2 and ChAdOx1 nCoV-19 COVID-19 vaccination at preventing hospitalisations in people aged at least 80 years: a test-negative, case-control study

Catherine Hyams et al.

Summary: The study found that one dose of either the BNT162b2 or ChAdOx1 nCoV-19 vaccines resulted in substantial risk reductions for COVID-19-related hospitalisations in those aged over 80 years.

LANCET INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Emma Pritchard et al.

Summary: Results from the Office for National Statistics COVID-19 Infection Survey in the UK demonstrate that the ChAdOx1 nCoV-19 and BNT162b2 vaccines reduce the incidence of new SARS-CoV-2 infections by up to 65% with a single dose and up to 80% after two doses, with no significant differences in efficacy observed between the two vaccines.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Yinon M. Bar-On et al.

Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.

NEW ENGLAND JOURNAL OF MEDICINE (2021)