Journal
NATURE MEDICINE
Volume 27, Issue 12, Pages 2104-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-021-01586-1
Keywords
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Funding
- Wolfson Family Charitable Trust
- Edmond de Rothschild Foundations
- Fannie Sherr Fund
- Dr. Beth Rom-Rymer Stem Cell Research Fund
- Minerva Stiftung grant
- Israel Science Foundation [1486/16]
- Broad Institute-Israel Science Foundation [2615/18]
- European Research Council under the European Union [768956]
- Chan Zuckerberg Initiative [CZF2019-002434]
- network of Pancreatic Organ Donors with Diabetes (nPOD)
- Bert L. and N. Kuggie Vallee Foundation
- Howard Hughes Medical Institute
- University of Pittsburgh
- Yale University
- Binational Science Foundation [2019075]
- National Institute of Health (NIH) [R21TR002639, R21HD102565]
- European Research Council (ERC) [768956] Funding Source: European Research Council (ERC)
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Analysis of single-cell transcriptomics in human fetal and neonatal intestinal cells has revealed a subpopulation of enteroendocrine cells that produce insulin during development. This finding suggests a potential extra-pancreatic source of beta cells, providing a new avenue for diabetes treatment.
Single-cell transcriptomic analyses of human fetal and neonatal intestinal cells reveal a subpopulation of enteroendocrine cells that produce insulin during development. Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.
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