Journal
NATURE IMMUNOLOGY
Volume 23, Issue 2, Pages 275-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-021-01114-w
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Funding
- Italian Ministry of Health [COVID-2020-12371640]
- Italian Ministry of University and Research
- Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic)
- Banca Intesa San Paolo
- European Union [101003650]
- SNF (Swiss National Science Foundation) [31003A_182270]
- AMAF Monza ONLUS
- AIRCS
- Swiss National Science Foundation (SNF) [31003A_182270] Funding Source: Swiss National Science Foundation (SNF)
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This study demonstrates that selected human humoral fluid-phase pattern recognition molecules can interact with SARS-CoV-2 in COVID-19, including PTX3 and MBL, exerting antiviral activity and being associated with disease severity. These findings have important implications for resistance and pathogenesis of COVID-19.
The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID-19). The present study was designed to conduct a systematic investigation of the interaction of human humoral fluid-phase pattern recognition molecules (PRMs) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of 12 PRMs tested, the long pentraxin 3 (PTX3) and mannose-binding lectin (MBL) bound the viral nucleocapsid and spike proteins, respectively. MBL bound trimeric spike protein, including that of variants of concern (VoC), in a glycan-dependent manner and inhibited SARS-CoV-2 in three in vitro models. Moreover, after binding to spike protein, MBL activated the lectin pathway of complement activation. Based on retention of glycosylation sites and modeling, MBL was predicted to recognize the Omicron VoC. Genetic polymorphisms at the MBL2 locus were associated with disease severity. These results suggest that selected humoral fluid-phase PRMs can play an important role in resistance to, and pathogenesis of, COVID-19, a finding with translational implications. Stravalaci et al. examined recognition of SARS-CoV-2 by human soluble innate pattern recognition receptor. They report that pentraxin 3 and mannose-binding protein recognize viral nucleoprotein and spike, respectively. Mannose-binding lectin has antiviral activity, and human genetic polymorphisms of MBL2 are associated with more severe COVID-19.
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