Journal
NATURE GENETICS
Volume -, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-021-00948-2
Keywords
-
Categories
Funding
- Swedish Research Council [2017-02688, 2020-02191, 2015-2558, 2010-5983, 2012-5538, 2014-6395, 349-2006-237, 2009-1039, 2018-02635, 2015-06722]
- Vinnova Swelife grant [2017-05284]
- Academy of Finland [263401, 267882, 312063, 312072, 317599]
- Novo Nordisk Foundation [NNF18OC0034408]
- Scania University Hospital (ALF grant)
- Diabetes Wellness Sweden [25-420 PG]
- Swedish Heart and Lung Foundation [20180640]
- Swedish Diabetes Foundation [DIA2019-468, DIA2020-511]
- EFSD/Lilly European Diabetes Research Programme
- Hjelt Foundation
- Albert Pahlsson Research Foundation
- Crafoord Foundation [20180778, 20190912, 20200867, 20200828, 20200891]
- Ake Wiberg Foundation [M20-0214]
- Swedish Foundation for Strategic Research [IRC15-0067]
- Pfizer
- Vaasa Hospital District
- Jakobstadsnejden Heart Foundation
- Folkhalsan Research Foundation
- Ollqvist Foundation
- Sigrid Juselius Foundation
- University of Helsinki
- Nordic Center of Excellence in Disease Genetics
- European Union [EXGENESIS FP62004-005272, MOSAIC FP7-600914]
- Swedish Cultural Foundation in Finland
- Finnish Diabetes Research Foundation
- Foundation for Life and Health in Finland
- Signe and Ane Gyllenberg Foundation
- Finnish Medical Society
- Paavo Nurmi Foundation
- Helsinki University Hospital
- Perklen Foundation
- Narpes Health Care Foundation
- Ahokas Foundation
- Ministry of Education in Finland
- Municipal Heath Care Center and Hospital in Jakobstad
- Health Care Center in Vaasa
- Health Care Center in Narpes
- Health Care Center in Korsholm
- European Research Council under the European Union's Seventh Framework Programme (no. FP7/2007-2013)/ERC grant [269045]
- Innovative Medicines Initiative 2 Joint Undertaking [115881]
- Regeneron Pharmaceuticals
- Region Skane (Scania County)
- ANDIS steering committee
- Swedish Research Council [2018-02635, 2020-02191, 2017-02688, 2015-06722] Funding Source: Swedish Research Council
- European Research Council (ERC) [269045] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [312072, 317599, 317599] Funding Source: Academy of Finland (AKA)
Ask authors/readers for more resources
Genome-wide association and genetic risk score analyses reveal differences in genetic architecture among five subtypes of diabetes, with some subtypes showing unique genetic backgrounds indicating potential etiological differences.
Genome-wide association and genetic risk score analyses highlight differences in genetic architecture across five subtypes of diabetes. Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the Finnish DIREVA (Diabetes register in Vasa) and Botnia studies were used for replication. We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits. The severe insulin-resistant subtype was uniquely associated with GRS for fasting insulin but not with variants in the TCF7L2 locus or GRS reflecting insulin secretion. Further, an SNP (rs10824307) near LRMDA was uniquely associated with mild obesity-related diabetes. Therefore, we conclude that the subtypes have partially distinct genetic backgrounds indicating etiological differences.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available