Journal
INFECTION GENETICS AND EVOLUTION
Volume 43, Issue -, Pages 381-397Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2016.05.019
Keywords
Opisthorchis; Epidemiology; Transmission; Infectious disease; Host-parasite; Evolution
Categories
Funding
- Higher Education Research Promotion and National Research University Project of Thailand
- Office of the Higher Education Commission, through the Health Cluster (SHeP-GMS)
- Khon Kaen University, from the Thailand Research Fund (TRF) [RTA 5680006]
- National Institute of Allergy and Infectious Diseases (NIAID), NIH [P50AI098639]
- Department of Biology, Laurentian University, Sudbury, Ontario, Canada
Ask authors/readers for more resources
Stimulated largely by the availability of new technology, biomedical research at the molecular-level and chemical-based control approaches arguably dominate the field of infectious diseases. Along with this, the proximate view of disease etiology predominates to the exclusion of the ultimate, evolutionary biology-based, causation perspective. Yet, historically and up to today, research in evolutionary biology has provided much of the foundation for understanding the mechanisms underlying disease transmission dynamics, virulence, and the design of effective integrated control strategies. Here we review the state of knowledge regarding the biology of Asian liver Fluke-host relationship, parasitology, phylodynamics, drug-based interventions and liver Fluke-related cancer etiology from an evolutionary biology perspective. We consider how evolutionary principles, mechanisms and research methods could help refine our understanding of clinical disease associated with infection by Liver Flukes as well as their transmission dynamics. We identify a series of questions for an evolutionary biology research agenda for the liver Fluke that should contribute to an increased understanding of liver Fluke-associated diseases. Finally, we describe an integrative evolutionary medicine approach to liver Fluke prevention and control highlighting the need to better contextualize interventions within a broader human health and sustainable development framework. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available