4.8 Article

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Related references

Note: Only part of the references are listed.
Article Cell Biology

Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair

Annika Pfeiffer et al.

Summary: The research shows that DNA damage-induced SUMOylation signal leads to recruitment of two antagonizing proteins, promoting repair of DNA double-strand breaks. The recruitment of ataxin-3 not only depends on SUMOylation, but also on PARylation, ensuring that ataxin-3 only prevents premature removal of DNA repair proteins during the early phase of DNA damage response.

JOURNAL OF CELL SCIENCE (2021)

Article Multidisciplinary Sciences

Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

Man Pan et al.

Summary: The human AAA+protein p97 plays a crucial role in cellular protein homeostasis. The study reveals insights into the interaction between p97 and its co-factor Npl4, showing three distinct conformational states of Npl4 in complex with human p97, suggesting the essential role of seesaw motion in the unfolding activity of the p97 complex.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

Susan Kilgas et al.

Summary: The ATPase p97 interacts with the MRN complex on chromatin and inactivation of p97 affects DNA repair and radiosensitivity. Inhibition of p97 function increases tumor cell killing following ionizing radiation by promoting MRE11 nuclease accumulation, suggesting potential use of p97 inhibitors in radiotherapy patients.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

John Fielden et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

Zhong Y. Yeow et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

Zhengping Shao et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Oncology

Targeting Topoisomerase I in the Era of Precision Medicine

Anish Thomas et al.

CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

Abhay Narayan Singh et al.

EMBO JOURNAL (2019)

Article Pharmacology & Pharmacy

Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083

Wai Kwan Tang et al.

MOLECULAR PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Perez-Riverol et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Stefano Annunziato et al.

NATURE COMMUNICATIONS (2019)

Article Biochemical Research Methods

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Alexandra A. Duarte et al.

NATURE METHODS (2018)

Review Biochemistry & Molecular Biology

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function

Jan B. Heidelberger et al.

EMBO REPORTS (2018)

Review Biochemistry & Molecular Biology

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

Johannes van den Boom et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

SLFN11 Blocks Stressed Replication Forks Independently of ATR

Junko Murai et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

Evangelia K. Papachristou et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets

Dragomir B. Krastev et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

ADPriboDB: The database of ADP-ribosylated proteins

Christina A. Vivelo et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Zdenek Skrott et al.

NATURE (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

Stephen J. Pettitt et al.

SCIENTIFIC DATA (2017)

Article Biochemistry & Molecular Biology

Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex

Nicholas O. Bodnar et al.

Article Biochemistry & Molecular Biology

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

Ian Gibbs-Seymour et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

System-wide identification of wild-type SUMO-2 conjugation sites

Ivo A. Hendriks et al.

NATURE COMMUNICATIONS (2015)

Article Biochemical Research Methods

Directed evolution of APEX2 for electron microscopy and proximity labeling

Stephanie S. Lam et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

Ubiquitin Signals Proteolysis-Independent Stripping of Transcription Factors

Ada Ndoja et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

Yingqi Xu et al.

NATURE COMMUNICATIONS (2014)

Article Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai et al.

CANCER RESEARCH (2012)

Review Cell Biology

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

Hemmo Meyer et al.

NATURE CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

Malavika Raman et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

A hyperactive piggyBac transposase for mammalian applications

Kosuke Yusa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes

Hyunju Ryu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

Nadine Martin et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Yaron Galanty et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3

Limin Gong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4

HH Meyer et al.

EMBO JOURNAL (2002)