4.8 Editorial Material

LONP-1 aids propagation of deleterious mtDNA

Related references

Note: Only part of the references are listed.
Article Cell Biology

LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria

Qiyuan Yang et al.

Summary: ATFS-1 preferentially accumulates in dysfunctional mitochondria carrying mutated mitochondrial DNA (increment mtDNA) and facilitates mtDNA replication by promoting POLG recruitment. Inhibition of LONP-1 can improve heteroplasmy ratio and restore mitochondrial function.

NATURE CELL BIOLOGY (2022)

Review Cell Biology

The Cellular Mitochondrial Genome Landscape in Diesease

Anne Hahn et al.

TRENDS IN CELL BIOLOGY (2019)

Article Cell Biology

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

Bryan L. Gitschlag et al.

CELL METABOLISM (2016)

Article Biochemistry & Molecular Biology

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Christopher J. Fiorese et al.

CURRENT BIOLOGY (2016)

Article Multidisciplinary Sciences

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Amrita M. Nargund et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

Der-Fen Suen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)