Journal
NATURE CELL BIOLOGY
Volume 24, Issue 2, Pages 127-128Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-021-00838-z
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The integrity of mitochondrial DNA is crucial for energy synthesis. A recent study reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that propagates genomes with deleterious mutations.
The integrity of the mitochondrial genome (mitochondrial DNA) is crucial for energy synthesis in all complex life. A study now reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that preferentially propagates genomes carrying deleterious mutations.
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