4.8 Article

Malaria protection due to sickle haemoglobin depends on parasite genotype

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Describing the current status of Plasmodium falciparum population structure and drug resistance within mainland Tanzania using molecular inversion probes

Kara A. Moser et al.

Summary: The study utilized high-throughput Plasmodium genomic data to analyze parasite population structure and geographic distribution of drug resistance mutations in Tanzania nationwide. The results indicated clear genetic separation between parasites from the northern and southern regions, with more drug resistance mutations found in the northern districts. The Malaria Indicator Survey data corresponded with genetic findings, providing insights into local genetic diversity and transmission patterns of malaria parasites.

MOLECULAR ECOLOGY (2021)

Article Microbiology

Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum

Joseph W. Saelens et al.

Summary: Sickle-trait hemoglobin (HbAS) provides almost complete protection from severe malaria, and the study reveals that Plasmodium falciparum adapts to HbAS by altering its protein chaperone and folding machinery, oxidative stress response, and protein export machinery.

MSPHERE (2021)

Review Parasitology

Defining the Essential Exportome of the Malaria Parasite

Thorey K. Jonsdottir et al.

Summary: Malaria parasites export proteins to alter their host cell's properties, with about 20% of these proteins being essential for parasite survival in culture. However, little is known about the biological functions of these essential proteins. By combining information from genetic screens and gene-disruption studies, researchers have tabulated all known exported proteins and discussed the essential pathways they may be involved in.

TRENDS IN PARASITOLOGY (2021)

Review Genetics & Heredity

Human genetics and malaria resistance

Silvia N. Kariuki et al.

HUMAN GENETICS (2020)

Article Multidisciplinary Sciences

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

Robert Verity et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

John A. Lees et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Alfred Amambua-Ngwa et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

Genenames.org: the HGNC and VGNC resources in 2019

Bryony Braschi et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Biotechnology & Applied Microbiology

The genomic architecture of antimalarial drug resistance

Annie N. Cowell et al.

BRIEFINGS IN FUNCTIONAL GENOMICS (2019)

Article Biochemical Research Methods

Minimap2: pairwise alignment for nucleotide sequences

Heng Li

BIOINFORMATICS (2018)

Article Multidisciplinary Sciences

Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition

Natasha M. Archer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Resistance to malaria through structural variation of red blood cell invasion receptors

Ellen M. Leffler et al.

SCIENCE (2017)

Review Microbiology

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

Alan F. Cowman et al.

CELL HOST & MICROBE (2017)

Article Biochemistry & Molecular Biology

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

Nuala A. O'Leary et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

Alistair Miles et al.

GENOME RESEARCH (2016)

Review Microbiology

Immune Escape Strategies of Malaria Parasites

Pollyanna S. Gomes et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Mathematical & Computational Biology

Penalization, bias reduction, and default priors in logistic and related categorical and survival regressions

Sander Greenland et al.

STATISTICS IN MEDICINE (2015)

Reprint Public, Environmental & Occupational Health

Limitations of the Application of Fourfold Table Analysis to Hospital Data (Reprinted from Biometrics Bulletin, vol 2, pg 47-53, 1946)

Joseph Berkson

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2014)

Article Genetics & Heredity

Reappraisal of known malaria resistance loci in a large multicenter study

Kirk A. Rockett et al.

NATURE GENETICS (2014)

Article Microbiology

Uncovering Common Principles in Protein Export of Malaria Parasites

Christof Gruering et al.

CELL HOST & MICROBE (2012)

Review Cell Biology

The cellular and molecular basis for malaria parasite invasion of the human red blood cell

Alan F. Cowman et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population

Hsiao-Han Chang et al.

MOLECULAR BIOLOGY AND EVOLUTION (2012)

Article Multidisciplinary Sciences

Genome-wide association study indicates two novel resistance loci for severe malaria

Christian Timmann et al.

NATURE (2012)

Article Multidisciplinary Sciences

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Magnus Manske et al.

NATURE (2012)

Article Multidisciplinary Sciences

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

Daniel J. Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Hematology

Sickle Cell Anaemia and Malaria

Lucio Luzzatto

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2012)

Article Biochemistry & Molecular Biology

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

Thomas D. Otto et al.

MOLECULAR MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

Ilaria Russo et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

PlasmoDB: a functional genomic database for malaria parasites

Cristina Aurrecoechea et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin

Rushina Cholera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemical Research Methods

Food vacuole proteome of the malarial parasite Plasmodium falciparum

Mauld Lamarque et al.

PROTEOMICS CLINICAL APPLICATIONS (2008)

Article Multidisciplinary Sciences

Sexual Population Structure and Genetics of the Malaria Agent P. falciparum

Themba Mzilahowa et al.

PLOS ONE (2007)

Article Biochemistry & Molecular Biology

Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum

Lara L. Bethke et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2006)

Article Medicine, General & Internal

An immune basis for malaria protection by the sickle cell trait

TN Williams et al.

PLOS MEDICINE (2005)

Review Microbiology

Metabolic maps and functions of the Plasmodium falciparum apicoplast

SA Ralph et al.

NATURE REVIEWS MICROBIOLOGY (2004)

Article Multidisciplinary Sciences

Targeting malaria virulence and remodeling proteins to the host erythrocyte

M Marti et al.

SCIENCE (2004)

Article Statistics & Probability

The positive false discovery rate: A Bayesian interpretation and the q-value

JD Storey

ANNALS OF STATISTICS (2003)