Journal
NATURAL PRODUCT RESEARCH
Volume 37, Issue 9, Pages 1544-1549Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2025591
Keywords
Artemisia vulgaris; Asteraceae; vulgaroside A; vulgaroside B; cytotoxic activity
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In this study, two new sesquiterpene glucosides were isolated from Artemisia vulgaris, and their chemical structures were determined using spectroscopic methods. The cytotoxicity of these compounds on five human cancer cell lines was evaluated, but no significant cytotoxicity was observed.
Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A (1) and B (2), and two known analogs ainsliaside E (3) and pumilaside A (4) were isolated from the aerial parts of Artemisia vulgaris. Their chemical structures were established by spectroscopic methods, including one and two-dimensional nuclear magnetic resonance (1 D and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). In addition, their cytotoxicity on five human cancer cell lines, including KB (epidermoid carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), SK-Mel-2 (melanoma), and LNCaP (prostate cancer) was also evaluated by the SRB assay. However, none of the tested eudesmane sesquiterpene glycosides showed significant cytotoxicity (IC50>100 mu M).
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