Journal
NATURAL PRODUCT RESEARCH
Volume 37, Issue 7, Pages 1138-1145Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1994564
Keywords
Lysimachia baviensis; Primulaceae; C-acetylstilbene; carbomethyl chalcone
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The chemical composition and anti-inflammatory activity of the endemic Lysimachia baviensis were studied for the first time in this research. A new stilbene and two new chalcone glycosides were isolated from the methanol extract of L. baviensis. These compounds showed strong inhibition of nitric oxide production in LPS-induced cells.
The chemical composition and anti-inflammatory activity of the endemic Lysimachia baviensis were investigated for the first time in this study. A phytochemical fractionation of the methanol extract of L. baviensis resulted in the isolation of a new stilbene (bavienside A, 1) and two new chalcone glycosides (baviensides B and C, 2 and 3). Their structures were elucidated via the interpretation of NMR and HRESIMS spectroscopic data. Compounds 1-3 strongly inhibited the production of nitric oxide in LPS-induced RAW264.7 cells with the IC50 values of 6.23, 2.86 and 3.51 mu M, respectively. The C-acetylstilbene and carbomethyl chalcone structures in compound 1 and 3 were found for the first time from natural source and could be important markers for chemotaxonomy of Lysimachia baviensis.
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