Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 22, Pages 5904-5909Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.2023865
Keywords
Netzahualcoyonol; Celastraceae; Salacia multiflora (Lam; ) DC; antibacterial; gram-positive; antibiofilm; synergism
Categories
Funding
- Fundacao de Amparoa Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Coordenacao de Aperfeicoamento de Pessoal do Nivel Superior (CAPES)
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Netzahualcoyonol has bacteriostatic and bactericidal effects against Gram-positive bacteria, disrupts S. aureus biofilm, shows synergistic effects with beta-lactams and aminoglycosides, and has low cytotoxicity, indicating a promising potential as a new effective antibacterial agent.
The expression of virulence factors, such as biofilm formation, in association with the acquisition of resistance to multiple drugs, has evidenced the need for new and effective antimicrobial agents against Staphylococcus aureus. The evaluation of the pharmacological properties of plant-derived compounds is a promising alternative to the development of new antimicrobials. In this study, we aimed to evaluate the antibacterial, antibiofilm, and the synergistic and cytotoxic effects of netzahualcoyonol isolated from Salacia multiflora (Lam.) DC. roots. Netzahualcoyonol presented bacteriostatic (1.56-25.0 mu g/mL) and bactericidal (25.0-400.0 mu g/mL) effects against Gram-positive bacteria, disrupted the biofilm of S. aureus, and presented a synergistic effect after its combination with beta-lactams and aminoglycosides. The low cytotoxicity of netzahualcoyonol (Selectivity Index (SI) for S. aureus (2.56), S. saprophyticus (20.56), and Bacillus subtilis (1.28)) suggests a good security profile. Taken together, these results show that netzahualcoyonol is promising for the development of a new effective antibacterial agent.
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