Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 17, Pages 4364-4370Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1986711
Keywords
Anti-inflammatory; phloroglucinols; Rutaceae; Acronychia crassipetala; TNF-alpha
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Two new phloroglucinols, acronyols A (1) and B (2), along with four known phloroglucinols (3-6) were identified from the fruits of Acronychia crassipetala. These compounds were evaluated for their inhibitory effects on NO production and downregulation of TNF-alpha in RAW 264.7 macrophage cell lines, showing promising anti-inflammatory activities.
Two new phloroglucinols, acronyols A (1) and B (2) along with the four known (3-6) pholoroglucinols were identified following anti-inflammatory activity guided fractionation from the fruits of Acronychia crassipetala (family Rutaceae). The pholoroglucinols (1-6) were evaluated for their inhibitory effects on NO production and downregulation of TNF-alpha in RAW 264.7 macrophage cell lines. [GRAPHICS] .
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