Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 23, Pages 6039-6043Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2041010
Keywords
alpha-Amylase inhibitory activity; C-benzylated flavone; alpha-glucosidase inhibitory activity; Uvaria rufa Blume
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Funding
- Thailand Science Research and Innovation [DBG6280007]
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A new C-benzylated flavone, uvariaruflavone (1), and 13 known compounds (2-14) were isolated from Uvaria rufa Blume. Uvariaruflavone (1) exhibited the highest α-glucosidase inhibitory activity, while ferrudiol (12) showed the highest α-amylase inhibitory activity.
A new C-benzylated flavone, uvariaruflavone (1), along with 13 known compounds (2-14) were isolated from the twig and leaf extracts of Uvaria rufa Blume. Their structures were established by extensive spectroscopic methods. Flavones (5-8) and cyclohexene (10) were isolated from U. rufa for the first time. Most of the isolated compounds were evaluated for their alpha-glucosidase and alpha-amylase inhibitory activities. Of these, uvariaruflavone (1) showed the highest alpha-glucosidase inhibitory activity with an IC50 value of 44.3 mu M, while ferrudiol (12) displayed the highest alpha-amylase inhibitory activity with an IC50 value of 73.5 mu M. [GRAPHICS] .
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