New prenylated flavonoid glycosides from the stems of Celastrus orbiculatus with their anti-tumor activities

Two new prenylated flavonoid glycosides (1-2), together with five known compounds (3-7) were isolated from the EtOAc-soluble extract of the stems of Celastrus orbiculatus. The structures of new compounds were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against HepG2, MCF-7, A549, and A2780 cancer cells. Among them, compound 1 showed potential antiproliferative activity on A2780 cells with IC50 value of 10.76 mu M. In addition, compound 2 exhibited selective cytotoxic activity on A2780 cells with IC50 value of 26.30 mu M.

Automated summary

Two new prenylated flavonoid glycosides were isolated from the stems of Celastrus orbiculatus, along with five known compounds. The structures of the new compounds were determined, and their cytotoxic activities were evaluated. Compound 1 showed potential antiproliferative activity on A2780 cells, while compound 2 exhibited selective cytotoxic activity on A2780 cells.