A new cyclopentenone derivative from Trichoderma atroviride HH-01

A new cyclopentenone derivative, atrovinol (1), together with ten known compounds (2-11) were isolated from Trichoderma atroviride HH-01, an endophytic fungus from Illigera rhodantha (Hernandiaceae). Their structures were identified by HRESIMS, 1 D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 exhibited moderate inhibitory activity against Staphylococcus aureus and Bacillus subtilis with MIC values of 8.0 mu g/mL and 16.0 mu g/mL, respectively.

Automated summary

A new compound, atrovinol, along with ten known compounds, was isolated from Trichoderma atroviride HH-01, an endophytic fungus from Illigera rhodantha. The structure of atrovinol was identified using various techniques, and it showed moderate inhibitory activity against Staphylococcus aureus and Bacillus subtilis.