Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 16, Issue 11, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X211059010
Keywords
bannaxanthone E; Garcinia mckeaniana; apoptosis; cell cycle; Hoechst 33342; caspase 3; 7 activation
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Funding
- Institute of Chemistry [2021]
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The study revealed that bannaxanthone E exhibited anti-cancer activity against SK-LU-1 lung cancer cells by inhibiting cell cycle progression and inducing apoptosis.
The anti-cancer activity of bannaxanthone E isolated from Garcinia mckeaniana leaves was assessed through a flow cytometric method on human lung SK-LU-1 cancer cells, including cell cycle changes and induction of cell apoptosis. Treatment with bannaxanthone E led to the suppression of cell cycle progression at the G2/M phase to 19.6% at 4 mu M, and induced apoptosis via cell morphological changes, increased the fluorescence signal in caspase-3/7 activation, and accumulation of apoptotic cells in the SK-LU-1 line at 4 mu M to 25.7%.
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