Journal
NANOSCALE
Volume 14, Issue 10, Pages 3731-3737Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nr06966g
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Funding
- Department of the Navy, Office of Naval Research (ONR) [N00014-20-1-2418]
- National Institutes of Health, National Institute on Deafness and Other Communication Disorders [NIHDC016644]
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CeO2-x nanorods with optimized aspect ratio demonstrated strong antiviral efficacies against human coronavirus OC43.
Despite the excellent antibacterial and antifouling effects of haloperoxidase (HPO)-mimicking CeO2-x nanorods, their antiviral efficiency has not been explored. Herein, we designed and synthesized CeO2-x nanorods with varying aspect ratios via the hydrothermal method. CeO2-x nanorods catalysed the oxidative bromination of Br- and H2O2 to HOBr, the kinetics of which were studied systematically using a phenol red assay. The CeO2-x nanorods with the optimized aspect ratio (i.e., 4.5) demonstrated strong antiviral efficacies against the human coronavirus OC43, with no visible toxicity to the HCT-8 host cells.
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