A review of recent advances in magnetic nanoparticle-based theranostics of glioblastoma

Lay abstract Glioblastoma multiforme is the most aggressive and deadly form of brain cancer. Currently available treatment methods such as chemotherapy, surgery and radiotherapy are not often successful. This leads to fast disease progression and a maximum survival of 15 months. Magnetic nanoparticles, due to their unique features, could be a suitable tool for treating and diagnosing glioblastoma. This review article discusses their potential in this field. Rapid vascular growth, infiltrative cells and high tumor heterogenicity are some glioblastoma multiforme (GBM) characteristics, making it the most lethal form of brain cancer. Low efficacy of the conventional treatment modalities leads to rampant disease progression and a median survival of 15 months. Magnetic nanoparticles (MNPs), due to their unique physical features/inherent abilities, have emerged as a suitable theranostic platform for targeted GBM treatment. Thus, new strategies are being designed to enhance the efficiency of existing therapeutic techniques such as chemotherapy, radiotherapy, and so on, using MNPs. Herein, the limitations of the current therapeutic strategies, the role of MNPs in mitigating those inadequacies, recent advances in the MNP-based theranostics of GBM and possible future directions are discussed.

Automated summary

Glioblastoma multiforme (GBM) is the most aggressive and deadly form of brain cancer. The currently available treatment methods often fail to be successful, leading to rapid disease progression and short survival time. Magnetic nanoparticles (MNPs) show great potential in targeted treatment of GBM due to their unique physical features. This review discusses the limitations of current therapeutic strategies and the role of MNPs in overcoming these limitations, as well as recent advances and future directions of MNP-based theranostics for GBM.