Journal
NANO TODAY
Volume 42, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2021.101361
Keywords
Liquid biopsy; Circulating tumor cells; Extracellular vesicles; Circulating tumor DNA; Nanotechnology; Nanoparticles; Nanostructured substrates
Categories
Funding
- National Science Foundation of China [82003689]
- Outstanding Young Scientific Talent Foundation of Sichuan Province [22JCQN0053]
- China Postdoctoral Science Foundation [2021M690489]
- International Postdoctoral Exchange Fellowship Program
- U.S. METAvivor Early Career Investigator Award [2018A020560]
- Harvard Medical School/Brigham and Women's Hospital Department of Anesthesiology Basic Scientist Grant [2420 BPA075]
- Center for Nanomedicine Research Fund [2019A014810]
- Khoury Innovation Award [2020A003219]
- American Heart Association (AHA) Collaborative Science Award [2018A004190]
- Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award [113548]
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Liquid biopsy allows for quick and noninvasive detection of tumor-associated components, providing great potential for tracking tumor dynamics, detecting early therapeutic resistance, and tumor recurrence. Advances in nanotechnology have contributed to the development of blood-based liquid biopsy with higher sensitivity and specificity.
Liquid biopsy allows for the quick and noninvasive detection of tumor-associated components. Various liquid biopsy components, which include circulating tumor cells, tumor-derived extracellular vesicles, circulating tumor nucleic acids, and tumor-educated platelets, can be analyzed. These components hold great potential for tracking the evolutionary dynamics of tumors and detecting the early emergence of therapeutic resistance and tumor recurrence. In recent decades, significant advances in nanotechnology have contributed to the development of blood-based liquid biopsy with higher sensitivity and specificity. This review discusses the key nanotechnologies that can be used to detect, isolate, and recover tumor-associated components, providing a brief overview of the downstream analysis of these components and then focusing on the different types of nanomaterials that can be applied for the treatment of circulating tumor cells to prevent metastasis. Taken together, these noninvasive nanotechnology-mediated diagnostic approaches can aid precise cancer assessment and guide modifications to current treatment strategies.(c) 2021 Elsevier Ltd. All rights reserved.
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