Continuous synthesis of ultrasmall core-shell upconversion nanoparticles via a flow chemistry method

A continuous synthesis method for the less than 10 nm core-shell upconversion nanoparticles was developed via coiled tube embedded flask reactors and a flow solvothermal co-participation reaction up to 300 degrees C. Fast nucleation of hexagonal nanocrystals in less than 9 min residence time was achieved owing to the excellent heating ability of the reactors, and a two-step reaction strategy was created for the synthesis of beta-NaYF4:Gd,Yb,Er/Ho/Tm@NaYF4 particles without intermediate purification.

Automated summary

A continuous synthesis method for core-shell upconversion nanoparticles of less than 10 nm was developed using coiled tube embedded flask reactors and a flow solvothermal co-participation reaction, achieving fast nucleation of hexagonal nanocrystals in less than 9 min residence time. A two-step reaction strategy was created for the synthesis of beta-NaYF4:Gd,Yb,Er/Ho/Tm@NaYF4 particles without intermediate purification.