Journal
NANO RESEARCH
Volume 15, Issue 4, Pages 3346-3355Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-021-3866-1
Keywords
aminated fullerene; autophagic flux; G0/G1 phase arrest; post-transcription regulation
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Funding
- National Natural Science Foundation of China [51802310]
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Functional fullerene derivatives have shown inhibitory effects on tumor progress and metastasis by regulating tumor microenvironment, but the molecular mechanisms remain unknown. This study demonstrates that nanosize aminated fullerene can activate autophagic flux, induce G0/G1 cell cycle arrest, and inhibit tumor growth by promoting the expression of cathepsin D. This work reveals the anti-tumor activity of aminated fullerene, elucidates the molecular mechanism, and provides a new strategy for antineoplastic drug development.
Functional fullerene derivatives exhibit special inhibitory effects on tumor progress and metastasis via diverse tumor microenvironment regulations, while the elusive molecular mechanisms hinder their clinical transformation. Herein, it is initially revealed that nanosize aminated fullerene (C-70-EDA) can activate autophagic flux, induce G0/G1 cell cycle arrest to abrogate cancer cell proliferation, and significantly inhibit tumor growth in vivo. Mechanismly, C-70-EDA promotes the expression of cathepsin D involved in autophagic activation via post-transcriptional regulation, attributing to the interaction with a panel of RNA binding proteins. The accumulation of cathepsin D induces the autophagic degradation of cyclin D1, which arouses G0/G1 phase arrest. This work unveils the fantastic anti-tumor activity of aminated fullerene, elucidates the molecular mechanism, and provides a new strategy for the antineoplastic drug development on functional fullerenes.
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