4.4 Article

Effective Antibiotic Conservation by Emergency Antimicrobial Stewardship During a Drug Shortage

Journal

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
Volume 38, Issue 3, Pages 356-359

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/ice.2016.289

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Funding

  1. Centers for Disease Control and Prevention Safety and Healthcare Epidemiology Prevention Research Development Grant [2015-010]

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We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam by 73%. During the shortage period, hospital mortality decreased (P=.03), while hospital length of stay remained unchanged. Infect Control Hosp Epidemiol 2017;38:356-359

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