Journal
MYCOPATHOLOGIA
Volume 187, Issue 1, Pages 129-131Publisher
SPRINGER
DOI: 10.1007/s11046-021-00602-9
Keywords
Histoplasma; Histoplasmosis; Antigen; Enzyme immunoassay
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The sandwich enzyme immunoassay developed by OIDx for Histoplasma urinary Ag showed high sensitivity, but had a high rate of false-positive results in non-histoplasmosis cases.
A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.
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