Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 28, Issue 7, Pages 1126-1130Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/13524585211046786
Keywords
Ocrelizumab; SARS-COV-2; COVID-19; vaccination; antibodies
Categories
Funding
- Wellcome Trust [220554/Z/20/Z]
- Wellcome Trust [220554/Z/20/Z] Funding Source: Wellcome Trust
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Real-world investigation on ocrelizumab recipients showed that the humoral response after a single dose of COVID-19 vaccine is lower than expected in CD20-deplete patients. However, the second vaccine dose was able to convert a significant portion of non-responders to seroconverters, indicating a potential improvement in immunogenicity.
Background: Despite impressive efficacy in immunocompetent individuals, the immunogenicity of a single dose of COVID-19 vaccine in B-cell-deplete patients remains unknown. Objectives: We aimed to quantify real-world vaccine immunogenicity in ocrelizumab recipients. Methods: We measured post-vaccination SARS-COV-2 immunoglobulin G (IgG) in ocrelizumab recipients using a highly sensitive Luminex assay. Results: 44.1% of patients had detectable SARS-COV-2-IgG 21+ days after one vaccine dose, regardless of vaccine type (AZD1222 vs BNT162b2, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.157-2.32, p = 0.72). B-cell count strongly predicted seroconversion (beta 1 = 12.38, 95% CI = 4.59-20.16, p = 0.0029), but undetectable B-cells did not preclude it. The second vaccine seroconverted 53% of the patients who had not already responded to dose 1. Conclusion: Humoral response after one COVID-19 vaccine dose is lower than expected in CD20-deplete patients.
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