Journal
MUCOSAL IMMUNOLOGY
Volume 15, Issue 2, Pages 223-234Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/s41385-021-00480-w
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Funding
- Wellcome Trust/Royal Society [206234/Z/17/Z]
- Medical Research Council UK
- Wellcome Trust [206234/Z/17/Z] Funding Source: Wellcome Trust
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The last decade has seen significant advances in the field of macrophage biology, particularly in our understanding of their heterogeneity, ontogeny, metabolism, and function in both health and disease. Future research should focus on further advancing core concepts and addressing key unanswered questions.
The last decade has been somewhat of a renaissance period for the field of macrophage biology. This renewed interest, combined with the advent of new technologies and development of novel model systems to assess different facets of macrophage biology, has led to major advances in our understanding of the diverse roles macrophages play in health, inflammation, infection and repair, and the dominance of tissue environments in influencing all of these areas. Here, we discuss recent developments in our understanding of lung macrophage heterogeneity, ontogeny, metabolism and function in the context of health and disease, and highlight core conceptual advances and key unanswered questions that we believe should be focus of work in the coming years.
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