A spotlight on heightened T cell complexity and relevance in mucosal tissues

Review Immunology

Human mucosal tissue-resident memory T cells in health and disease

Joshua Lange et al.

Summary: Memory T cells, specifically non-recirculating resident memory T cells (TRMs), play a crucial role in maintaining immune surveillance and forming first line memory responses in tissues to prevent re-infections. Understanding the heterogeneity and unique functions of TRMs at diverse tissue sites will help shape future vaccine and immunotherapeutic approaches to target invading pathogens and developing tumor cells.

MUCOSAL IMMUNOLOGY (2022)

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Review Immunology

The fellowship of regulatory and tissue-resident memory cells

Leandro Barros et al.

Summary: T cells located in non-lymphoid tissues, including CD8(+) Trm cells and CD4(+) Treg cells, have functions beyond immune defence, involving tissue homeostasis and repair. They form a multicellular communication network and have potential implications for future therapies.

MUCOSAL IMMUNOLOGY (2022)

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Review Immunology

Tissue resident memory T cells in the respiratory tract

Ming Z. M. Zheng et al.

Summary: Tissue-resident memory (Trm) cells in the respiratory tract play a crucial role in local immune responses against infections. Factors influencing the development, longevity, and immune surveillance of Trm cells were discussed, along with vaccination regimes harnessing these cells as new strategies to combat future global pandemics.

MUCOSAL IMMUNOLOGY (2022)

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Review Immunology

Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry

Brianna R. Traxinger et al.

Summary: Tregs are essential for preventing autoimmune diseases and maintaining immune balance, while also exhibiting tissue-specific functions and dynamic roles within different tissue compartments.

MUCOSAL IMMUNOLOGY (2022)

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Review Immunology