Journal
MOVEMENT DISORDERS
Volume 37, Issue 3, Pages 635-640Publisher
WILEY
DOI: 10.1002/mds.28870
Keywords
cognitive impairment; controlled trial; deep brain stimulation; globus pallidus pars interna; nucleus basalis of Meynert; Parkinson's disease
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Funding
- Chair in Neuromodulation and Multidisciplinary Care at the University of Toronto, Toronto, Ontario, Canada
- Chair in Neuromodulation and Multidisciplinary Care at the University Health Network, Toronto, Ontario, Canada
- Canadian Institutes of Health Research
- Krembil-Rossy Chair
- Canadian Institutes of Health Research (CIHR) [PJ8-1699695]
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The study found that simultaneous GPi and NBM stimulation is safe and improves motor complications in Parkinson's disease patients, but does not improve cognition. NBM stimulation has effects on brain metabolism and functional connectivity, but does not result in lasting cognitive improvement.
Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is an emerging target to potentially treat cognitive dysfunction. Objectives The aim of this study is to achieve feasibility and safety of globus pallidus pars interna (GPi) and NBM DBS in advanced PD with cognitive impairment. Methods We performed a phase-II double-blind crossover pilot trial in six participants to assess safety and cognitive measures, the acute effect of NBM stimulation on attention, motor and neuropsychological data at one year, and neuroimaging biomarkers of NBM stimulation. Results NBM DBS was well tolerated but did not improve cognition. GPi DBS improved dyskinesia and motor fluctuations (P = 0.04) at one year. NBM stimulation was associated with reduced right frontal and parietal glucose metabolism (P < 0.01) and increased low- and high-frequency power and functional connectivity. Volume of tissue activated in the left NBM was associated with stable cognition (P < 0.05). Conclusions Simultaneous GPi and NBM stimulation is safe and improves motor complications. NBM stimulation altered neuroimaging biomarkers but without lasting cognitive improvement. (c) 2021 International Parkinson and Movement Disorder Society
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