Journal
MOVEMENT DISORDERS
Volume 37, Issue 2, Pages 416-421Publisher
WILEY
DOI: 10.1002/mds.28846
Keywords
Parkinson's; Gaucher's; glucocerebrosidase; lipidomics
Categories
Funding
- Parkinson's Foundation
- Michael J. Fox Foundation
- National Institutes of Health [K02NS080915, UL1 TR000040]
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This study found significantly higher levels of plasma glucosylsphingosine in GBA1 N370S carriers, independent of disease status. This opens up the potential for future assessment of glucosylsphingosine as a clinically meaningful biomarker of GBA1-PD.
Background Biallelic mutations in the GBA1 gene encoding glucocerebrosidase cause Gaucher's disease, whereas heterozygous carriers are at risk for Parkinson's disease (PD). Glucosylsphingosine is a clinically meaningful biomarker of Gaucher's disease but could not be assayed previously in heterozygous GBA1 carriers. Objective The aim of this study was to assess plasma glucosylsphingosine levels in GBA1 N370S carriers with and without PD. Methods Glucosylsphingosine, glucosylceramide, and four other lipids were quantified in plasma from N370S heterozygotes with (n = 20) or without (n = 20) PD, healthy controls (n = 20), idiopathic PD (n = 20), and four N370S homozygotes (positive controls; Gaucher's/PD) using quantitative ultra-performance liquid chromatography tandem mass spectrometry. Results Plasma glucosylsphingosine was significantly higher in N370S heterozygotes compared with noncarriers, independent of disease status. As expected, Gaucher's/PD cases showed increases in both glucocerebrosidase substrates, glucosylsphingosine and glucosylceramide. Conclusions Plasma glucosylsphingosine accumulation in N370S heterozygotes shown in this study opens up its future assessment as a clinically meaningful biomarker of GBA1-PD. (c) 2021 International Parkinson and Movement Disorder Society
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