Journal
MOVEMENT DISORDERS
Volume 37, Issue 3, Pages 456-463Publisher
WILEY
DOI: 10.1002/mds.28892
Keywords
dystonia; white matter; oligodendrocyte; ECM; plasticity
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Funding
- National Institutes of Health, National Institute of Neurological Disorders and Stroke grant [1R01NS109227]
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The development of genomics and neuroimaging techniques has shed light on the importance of neuronal-glial interactions and extracellular matrix in nervous system development, function, and plasticity. Abnormalities in neuronal-glial interactions play a key role in neurodevelopmental disorders.
The quest to elucidate nervous system function and dysfunction in disease has focused largely on neurons and neural circuits. However, fundamental aspects of nervous system development, function, and plasticity are regulated by nonneuronal elements, including glial cells and the extracellular matrix (ECM). The rapid rise of genomics and neuroimaging techniques in recent decades has highlighted neuronal-glial interactions and ECM as a key component of nervous system development, plasticity, and function. Abnormalities of neuronal-glial interactions have been understudied but are increasingly recognized to play a key role in many neurodevelopmental disorders. In this report, we consider the role of myelination and the ECM in the development and function of central nervous system motor circuits and the neurodevelopmental disease dystonia. (c) 2022 International Parkinson and Movement Disorder Society
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